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WeightNameValue
1000 Titel
  • Nicotinic Acid Increases Adiponectin Secretion from Differentiated Bovine Preadipocytes through G-Protein Coupled Receptor Signaling
1000 Autor/in
  1. Kopp, Christina |
  2. Hosseini, Afshin |
  3. Singh, Shiva P. |
  4. Regenhard, Petra |
  5. Khalilvandi-Behroozyar, Hamed |
  6. Sauerwein, Helga |
  7. Mielenz, Manfred |
1000 Erscheinungsjahr 2014
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2014-11-18
1000 Erschienen in
1000 Quellenangabe
  • 15(11): 21401-21418
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2014
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.3390/ijms151121401 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264232/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The transition period in dairy cows (3 weeks prepartum until 3 weeks postpartum) is associated with substantial mobilization of energy stores, which is often associated with metabolic diseases. Nicotinic acid (NA) is an antilipolytic and lipid-lowering compound used to treat dyslipidaemia in humans, and it also reduces non-esterified fatty acids in cattle. In mice the G-protein coupled receptor 109A (GPR109A) ligand NA positively affects the secretion of adiponectin, an important modulator of glucose and fat metabolism. In cattle, the corresponding data linking NA to adiponectin are missing. Our objective was to examine the effects of NA on adiponectin and AMPK protein abundance and the expression of mRNAs of related genes such as chemerin, an adipokine that enhances adiponectin secretion in vitro. Differentiated bovine adipocytes were incubated with pertussis toxin (PTX) to verify the involvement of GPR signaling, and treated with 10 or 15 µM NA for 12 or 24 h. NA increased adiponectin concentrations (p ≤ 0.001) and the mRNA abundances of GPR109A (p ≤ 0.05) and chemerin (p ≤ 0.01). Pre-incubation with PTX reduced the adiponectin response to NA (p ≤ 0.001). The NA-stimulated secretion of adiponectin and the mRNA expression of chemerin in the bovine adipocytes were suggestive of GPR signaling-dependent improved insulin sensitivity and/or adipocyte metabolism in dairy cows.
1000 Sacherschließung
lokal nicotinic acid
lokal G-protein coupled receptor 109A
lokal adiponectin
lokal bovine adipocytes
lokal 5'-adenosine monophosphate-activated protein kinase
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/S29wcCwgQ2hyaXN0aW5h|https://frl.publisso.de/adhoc/creator/SG9zc2VpbmksIEFmc2hpbg==|https://frl.publisso.de/adhoc/creator/U2luZ2gsIFNoaXZhIFAu|https://frl.publisso.de/adhoc/creator/UmVnZW5oYXJkLCBQZXRyYQ==|https://frl.publisso.de/adhoc/creator/S2hhbGlsdmFuZGktQmVocm9venlhciwgSGFtZWQ=|https://frl.publisso.de/adhoc/creator/U2F1ZXJ3ZWluLCBIZWxnYQ==|https://frl.publisso.de/adhoc/creator/TWllbGVueiwgTWFuZnJlZA==
1000 Label
1000 Förderer
  1. University of Bonn |
  2. Indian Council of Agricultural Research (ICAR) |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. -
  2. International Fellowship
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer University of Bonn |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Indian Council of Agricultural Research (ICAR) |
    1000 Förderprogramm International Fellowship
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6405870.rdf
1000 Erstellt am 2017-12-14T16:47:07.742+0100
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1000 Zuletzt bearbeitet 2020-11-30T15:17:24.440+0100
1000 Objekt bearb. Mon Nov 30 15:17:24 CET 2020
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1000 Oai Id
  1. oai:frl.publisso.de:frl:6405870 |
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