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1000 Titel
  • Transcriptional responses of PBMC in psychosocially stressed animals indicate an alerting of the immune system in female but not in castrated male pigs
1000 Autor/in
  1. Oster, Michael |
  2. Muráni, Eduard |
  3. Ponsuksili, Siriluck |
  4. D’Eath, Richard B. |
  5. Turner, Simon P. |
  6. Evans, Gary |
  7. Thölking, Ludger |
  8. Kurt, Esra |
  9. Klont, Ronald |
  10. Foury, Aline |
  11. Mormède, Pierre |
  12. Wimmers, Klaus |
1000 Erscheinungsjahr 2014
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2014-11-08
1000 Erschienen in
1000 Quellenangabe
  • 15: 967
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2014
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/1471-2164-15-967 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233077/ |
1000 Ergänzendes Material
  • https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-15-967#Declarations |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Brain and immune system are linked in a bi-directional manner. To date, it remained largely unknown why immune components become suppressed, enhanced, or remain unaffected in relation to psychosocial stress. Therefore, we mixed unfamiliar pigs with different levels of aggressiveness. We separated castrated male and female pigs into psychosocially high- and low- stressed animals by skin lesions, plasma cortisol level, and creatine kinase activity obtained from agonistic behaviour associated with regrouping. Peripheral blood mononuclear cells (PBMC) were collected post-mortem and differential gene expression was assessed using the Affymetrix platform (n = 16). RESULTS: Relevant stress-dependent alterations were found only between female samples, but not between castrated male samples. Molecular routes related to TREM 1 signalling, dendritic cell maturation, IL-6 signalling, Toll-like receptor signalling, and IL-8 signalling were increased in high stressed females compared to low stressed females. This indicates a launch of immune effector molecules as a direct response. According to the shifts of transcripts encoding cell surface receptors (e.g. CD14, TLR2, TLR4, TREM1) the study highlights processes acting on pattern recognition, inflammation, and cell-cell communication. CONCLUSIONS: The transcriptional response partly affected the degree of ‘stress responsiveness’, indicating that the high stressed females altered their signal transduction due to potential infections and injuries while fighting.
1000 Fachgruppe
  1. Biologie |
  2. Medizin |
  3. Agrarwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/T3N0ZXIsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/creator/TXVyw6FuaSwgRWR1YXJk|https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1Y2s=|https://frl.publisso.de/adhoc/creator/ROKAmUVhdGgsIFJpY2hhcmQgQi4=|https://frl.publisso.de/adhoc/creator/VHVybmVyLCBTaW1vbiBQLg==|https://frl.publisso.de/adhoc/creator/RXZhbnMsIEdhcnk=|https://frl.publisso.de/adhoc/creator/VGjDtmxraW5nLCBMdWRnZXI=|https://frl.publisso.de/adhoc/creator/S3VydCwgRXNyYQ==|https://frl.publisso.de/adhoc/creator/S2xvbnQsIFJvbmFsZA==|https://frl.publisso.de/adhoc/creator/Rm91cnksIEFsaW5l|https://frl.publisso.de/adhoc/creator/TW9ybcOoZGUsIFBpZXJyZQ==|http://orcid.org/0000-0002-9523-6790
1000 Förderer
  1. European Union |
  2. Federal Ministry of Education and Research (BMBF) |
  3. Leibniz Institute for Farm Animal Biology (FBN) |
  4. PIC Germany |
  5. Institut national de la recherche agronomique (INRA) |
  6. Scottish Government |
1000 Fördernummer
  1. -
  2. 0315536F
  3. -
  4. -
  5. -
  6. -
1000 Förderprogramm
  1. 6th Research Framework Programme: SABRE project
  2. PHENOMICS project
  3. -
  4. -
  5. -
  6. Rural and Environment Science and Analytical Services (RESAS) Division
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Union |
    1000 Förderprogramm 6th Research Framework Programme: SABRE project
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Federal Ministry of Education and Research (BMBF) |
    1000 Förderprogramm PHENOMICS project
    1000 Fördernummer 0315536F
  3. 1000 joinedFunding-child
    1000 Förderer Leibniz Institute for Farm Animal Biology (FBN) |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer PIC Germany |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Institut national de la recherche agronomique (INRA) |
    1000 Förderprogramm -
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer Scottish Government |
    1000 Förderprogramm Rural and Environment Science and Analytical Services (RESAS) Division
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405876.rdf
1000 Erstellt am 2017-12-14T17:35:44.716+0100
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1000 Oai Id
  1. oai:frl.publisso.de:frl:6405876 |
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