WeightNameValue
1000 Titel
  • Dissection of Genetic Factors Modulating Fetal Growth in Cattle Indicates a Substantial Role of the Non-SMC Condensin I Complex, Subunit G (NCAPG) Gene
1000 Autor/in
  1. Eberlein, Annett |
  2. Takasuga, Akiko |
  3. Setoguchi, Kouji |
  4. Pfuhl, Ralf |
  5. Flisikowski, Krzysztof |
  6. Fries, Ruedi |
  7. Klopp, Norman |
  8. Fürbass, Rainer |
  9. Weikard, Rosemarie |
  10. Kühn, Christa |
1000 Erscheinungsjahr 2009
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2009-11-18
1000 Erschienen in
1000 Quellenangabe
  • 183(3): 951-964
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778990/ |
  • https://doi.org/10.1534/genetics.109.106476 |
1000 Ergänzendes Material
  • http://www.genetics.org/content/183/3/951.supplemental |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The increasing evidence of fetal developmental effects on postnatal life, the still unknown fetal growth mechanisms impairing offspring generated by somatic nuclear transfer techniques, and the impact on stillbirth and dystocia in conventional reproduction have generated increasing attention toward mammalian fetal growth. We identified a highly significant quantitative trait locus (QTL) affecting fetal growth on bovine chromosome 6 in a specific resource population, which was set up by consistent use of embryo transfer and foster mothers and, thus, enabled dissection of fetal-specific genetic components of fetal growth. Merging our data with results from other cattle populations differing in historical and geographical origin and with comparative data from human whole-genome association mapping suggests that a nonsynonymous polymorphism in the non-SMC condensin I complex, subunit G (NCAPG) gene, NCAPG c.1326T>G, is the potential cause of the identified QTL resulting in divergent bovine fetal growth. NCAPG gene expression data in fetal placentomes with different NCAPG c.1326T>G genotypes, which are in line with recent results about differential NCAPG expression in placentomes from studies on assisted reproduction techniques, indicate that the NCAPG locus may give valuable information on the specific mechanisms regulating fetal growth in mammals.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/RWJlcmxlaW4sIEFubmV0dA==|https://frl.publisso.de/adhoc/creator/VGFrYXN1Z2EsIEFraWtv|https://frl.publisso.de/adhoc/creator/U2V0b2d1Y2hpLCBLb3VqaQ==|https://frl.publisso.de/adhoc/creator/UGZ1aGwsIFJhbGY=|https://frl.publisso.de/adhoc/creator/Rmxpc2lrb3dza2ksIEtyenlzenRvZg==|https://frl.publisso.de/adhoc/creator/RnJpZXMsIFJ1ZWRp|https://frl.publisso.de/adhoc/creator/S2xvcHAsIE5vcm1hbg==|https://frl.publisso.de/adhoc/creator/RsO8cmJhc3MsIFJhaW5lcg==|https://frl.publisso.de/adhoc/creator/V2Vpa2FyZCwgUm9zZW1hcmll|https://frl.publisso.de/adhoc/creator/S8O8aG4sIENocmlzdGE=
1000 Label
1000 Förderer
  1. German Federal Ministry of Education and Research |
1000 Fördernummer
  1. FKZ 0313391C
1000 Förderprogramm
  1. FUGATO QUALIPID project
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Education and Research |
    1000 Förderprogramm FUGATO QUALIPID project
    1000 Fördernummer FKZ 0313391C
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6406073.rdf
1000 Erstellt am 2018-01-02T16:07:24.688+0100
1000 Erstellt von 25
1000 beschreibt frl:6406073
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Nov 26 14:12:50 CET 2020
1000 Objekt bearb. Thu Nov 26 14:12:49 CET 2020
1000 Vgl. frl:6406073
1000 Oai Id
  1. oai:frl.publisso.de:frl:6406073 |
1000 Sichtbarkeit Metadaten public
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