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1000 Titel
  • Association of HPA axis-related genetic variation with stress reactivity and aggressive behaviour in pigs
1000 Autor/in
  1. Muráni, Eduard |
  2. Ponsuksili, Siriluck |
  3. D'Eath, Richard B. |
  4. Turner, Simon P. |
  5. Kurt, Esra |
  6. Evans, Gary |
  7. Thölking, Ludger |
  8. Klont, Ronald |
  9. Foury, Aline |
  10. Mormède, Pierre |
  11. Wimmers, Klaus |
1000 Erscheinungsjahr 2010
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2010-08-09
1000 Erschienen in
1000 Quellenangabe
  • 11: 74
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2010
1000 Lizenz
1000 Verlagsversion
  • http://doi.org/10.1186/1471-2156-11-74 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927472/ |
1000 Ergänzendes Material
  • https://static-content.springer.com/esm/art%3A10.1186%2F1471-2156-11-74/MediaObjects/12863_2010_821_MOESM1_ESM.XLS |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Stress, elicited for example by aggressive interactions, has negative effects on various biological functions including immune defence, reproduction, growth, and, in livestock, on product quality. Stress response and aggressiveness are mutually interrelated and show large interindividual variation, partly attributable to genetic factors. In the pig little is known about the molecular-genetic background of the variation in stress responsiveness and aggressiveness. To identify candidate genes we analyzed association of DNA markers in each of ten genes (CRH g.233C>T, CRHR1 c.*866_867insA, CRHBP c.51G>A, POMC c.293_298del, MC2R c.306T>G, NR3C1 c.*2122A>G, AVP c.207A>G, AVPR1B c.1084A>G, UCN g.1329T>C, CRHR2 c.*13T>C) related to the hypothalamic-pituitary-adrenocortical (HPA) axis, one of the main stress-response systems, with various stress- and aggression-related parameters at slaughter. These parameters were: physiological measures of the stress response (plasma concentrations of cortisol, creatine kinase, glucose, and lactate), adrenal weight (which is a parameter reflecting activity of the central branch of the HPA axis over time) and aggressive behaviour (measured by means of lesion scoring) in the context of psychosocial stress of mixing individuals with different aggressive temperament. RESULTS: The SNP NR3C1 c.*2122A>G showed association with cortisol concentration (p = 0.024), adrenal weight (p = 0.003) and aggressive behaviour (front lesion score, p = 0.012; total lesion score p = 0.045). The SNP AVPR1B c.1084A>G showed a highly significant association with aggressive behaviour (middle lesion score, p = 0.007; total lesion score p = 0.003). The SNP UCN g.1329T>C showed association with adrenal weight (p = 0.019) and aggressive behaviour (front lesion score, p = 0.029). The SNP CRH g.233C>T showed a significant association with glucose concentration (p = 0.002), and the polymorphisms POMC c.293_298del and MC2R c.306T>G with adrenal weight (p = 0.027 and p < 0.0001 respectively). CONCLUSIONS: The multiple and consistent associations shown by SNP in NR3C1 and AVPR1B provide convincing evidence for genuine effects of their DNA sequence variation on stress responsiveness and aggressive behaviour. Identification of the causal functional molecular polymorphisms would not only provide markers useful for pig breeding but also insight into the molecular bases of the stress response and aggressive behaviour in general.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/TXVyw6FuaSwgRWR1YXJk|https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1Y2s=|https://frl.publisso.de/adhoc/creator/RCdFYXRoLCBSaWNoYXJkIEIu|https://frl.publisso.de/adhoc/creator/VHVybmVyLCBTaW1vbiBQLg==|https://frl.publisso.de/adhoc/creator/S3VydCwgRXNyYQ==|https://frl.publisso.de/adhoc/creator/RXZhbnMsIEdhcnk=|https://frl.publisso.de/adhoc/creator/VGjDtmxraW5nLCBMdWRnZXI=|https://frl.publisso.de/adhoc/creator/S2xvbnQsIFJvbmFsZA==|https://frl.publisso.de/adhoc/creator/Rm91cnksIEFsaW5l|https://frl.publisso.de/adhoc/creator/TW9ybcOoZGUsIFBpZXJyZQ==|http://orcid.org/0000-0002-9523-6790
1000 Label
1000 Förderer
  1. European Union European Commission |
  2. FBN |
  3. PIC |
  4. INRA |
  5. Rural and Environment Research and Analysis Directorate of the Scottish Government |
1000 Fördernummer
  1. -
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  3. -
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  5. -
1000 Förderprogramm
  1. 6th Research Framework Programme as part of the SABRE [Cutting-Edge Genomics for Sustainable Animal Breeding] Integrated Project
  2. -
  3. -
  4. -
  5. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Union European Commission |
    1000 Förderprogramm 6th Research Framework Programme as part of the SABRE [Cutting-Edge Genomics for Sustainable Animal Breeding] Integrated Project
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer FBN |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer PIC |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer INRA |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Rural and Environment Research and Analysis Directorate of the Scottish Government |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6406139.rdf
1000 Erstellt am 2018-01-04T14:27:04.946+0100
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