WeightNameValue
1000 Titel
  • Well-Defined, Multifunctional Nanostructures of a Paramagnetic Lipid and a Lipopeptide for Macrophage Imaging
1000 Autor/in
  1. Vucic, Esad |
  2. Sanders, Honorius M.H.F. |
  3. Arena, Francesca |
  4. Terreno, Enzo |
  5. Aime, Silvio |
  6. Nicolay, Klaas |
  7. Leupold, Eik |
  8. Dathe, Margitta |
  9. Sommerdijk, Nico A.J.M. |
  10. Fayad, Zahi A. |
  11. Mulder, Willem J.M. |
1000 Erscheinungsjahr 2008
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2008-12-23
1000 Erschienen in
1000 Quellenangabe
  • 131(2): 406–407
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305789/ |
  • http://doi.org/10.1021/ja808310u |
1000 Ergänzendes Material
  • http://pubs.acs.org/doi/suppl/10.1021/ja808310u |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • In the field of nanomedicine there is a great demand for technologies that allow the creation of self-assembled structures of which the size and morphology can be accurately controlled. In the current study, we report a nanoparticle platform that is composed of a paramagnetic lipid and a fluorescently labeled lipopeptide. By judiciously controlling the ratio of the aforementioned amphiphilic molecules, a variety of well-defined nanosized supramolecular structures with different sizes and morphologies could be created. The hydrodynamic radii of the different structures were determined by dynamic light scattering. Cryo-TEM revealed the aggregate morphology to vary from small micellar structures to plate-like and even full grown ribbons of which the aspect ratios varied from a diameter of 5−8 nm to structures with a width of up to 25 nm and infinite length. Interestingly, nuclear magnetic resonance dispersion profiling revealed excellent properties for MRI and also showed that the relaxivity of the structures was tunable and morphology dependent. Finally, macrophage cells were treated with two selected nanoparticles and were shown to be avidly taken up. In conclusion we demonstrate a methodology to create structures that (1) are paramagnetic to enable their detection with MRI, (2) exhibit fluorescent properties, (3) can be tuned to defined sizes and shapes, and (4) are efficiently taken up by macrophage cells in vitro.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/VnVjaWMsIEVzYWQ=|https://frl.publisso.de/adhoc/creator/U2FuZGVycywgSG9ub3JpdXMgTS5ILkYu|https://frl.publisso.de/adhoc/creator/QXJlbmEsIEZyYW5jZXNjYQ==|https://frl.publisso.de/adhoc/creator/VGVycmVubywgRW56bw==|https://frl.publisso.de/adhoc/creator/QWltZSwgU2lsdmlv|https://frl.publisso.de/adhoc/creator/Tmljb2xheSwgS2xhYXM=|https://frl.publisso.de/adhoc/creator/TGV1cG9sZCwgRWlr|https://frl.publisso.de/adhoc/creator/RGF0aGUsIE1hcmdpdHRh|https://frl.publisso.de/adhoc/creator/U29tbWVyZGlqaywgTmljbyBBLkouTS4=|https://frl.publisso.de/adhoc/creator/RmF5YWQsIFphaGkgQS4=|https://frl.publisso.de/adhoc/creator/TXVsZGVyLCBXaWxsZW0gSi5NLg==
1000 Label
1000 Förderer
  1. NIH/NHLBI |
  2. DFG |
1000 Fördernummer
  1. R01 HL71021; R01 HL78667
  2. DA 324/5-2; FG 463
1000 Förderprogramm
  1. -
  2. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer NIH/NHLBI |
    1000 Förderprogramm -
    1000 Fördernummer R01 HL71021; R01 HL78667
  2. 1000 joinedFunding-child
    1000 Förderer DFG |
    1000 Förderprogramm -
    1000 Fördernummer DA 324/5-2; FG 463
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6406168.rdf
1000 Erstellt am 2018-01-05T09:26:39.924+0100
1000 Erstellt von 25
1000 beschreibt frl:6406168
1000 Bearbeitet von 288
1000 Zuletzt bearbeitet 2022-08-18T07:45:08.714+0200
1000 Objekt bearb. Tue Mar 09 11:49:36 CET 2021
1000 Vgl. frl:6406168
1000 Oai Id
  1. oai:frl.publisso.de:frl:6406168 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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