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1000 Titel
  • Mitochondrial-nuclear crosstalk, haplotype and copy number variation distinct in muscle fiber type, mitochondrial respiratory and metabolic enzyme activities
1000 Autor/in
  1. Liu, Xuan |
  2. Trakooljul, Nares |
  3. Hadlich, Frieder |
  4. Murani, Eduard |
  5. Ponsuksili, Siriluck |
  6. Wimmers, Klaus |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-10-25
1000 Erschienen in
1000 Quellenangabe
  • 7:14024
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41598-017-14491-w |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41598-017-14491-w#Sec24 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Genes expressed in mitochondria work in concert with those expressed in the nucleus to mediate oxidative phosphorylation (OXPHOS), a process that is relevant for muscle metabolism and meat quality. Mitochondrial genome activity can be efficiently studied and compared in Duroc and Pietrain pigs, which harbor different mitochondrial haplotypes and distinct muscle fiber types, mitochondrial respiratory activities, and fat content. Pietrain pigs homozygous-positive for malignant hyperthermia susceptibility (PiPP) carried only haplotype 8 and showed the lowest absolute mtDNA copy number accompanied by a decrease transcript abundance of mitochondrial-encoded subunits ND1, ND6, and ATP6 and nuclear-encoded subunits NDUFA11 and NDUFB8. In contrast, we found that haplotype 4 of Duroc pigs had significantly higher mitochondrial DNA (mtDNA) copy numbers and an increase transcript abundance of mitochondrial-encoded subunits ND1, ND6, and ATP6. These results suggest that the variation in mitochondrial and nuclear genetic background among these animals has an effect on mitochondrial content and OXPHOS system subunit expression. We observed the co-expression pattern of mitochondrial and nuclear encoded OXPHOS subunits suggesting that the mitochondrial-nuclear crosstalk functionally involves in muscle metabolism. The findings provide valuable information for understanding muscle biology processes and energy metabolism, and may direct use for breeding strategies to improve meat quality and animal health.
1000 Sacherschließung
lokal Transcription
lokal Gene expression
1000 Fachgruppe
  1. Biologie |
  2. Agrarwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/TGl1LCBYdWFu|https://frl.publisso.de/adhoc/creator/VHJha29vbGp1bCwgTmFyZXM=|https://frl.publisso.de/adhoc/creator/SGFkbGljaCwgRnJpZWRlcg==|https://frl.publisso.de/adhoc/creator/TXVyYW5pLCBFZHVhcmQ=|https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1Y2s=|http://orcid.org/0000-0002-9523-6790
1000 Label
1000 Förderer
  1. German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6406193.rdf
1000 Erstellt am 2018-01-08T11:05:59.759+0100
1000 Erstellt von 122
1000 beschreibt frl:6406193
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 23:46:45 CET 2020
1000 Objekt bearb. Mon May 28 11:33:20 CEST 2018
1000 Vgl. frl:6406193
1000 Oai Id
  1. oai:frl.publisso.de:frl:6406193 |
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