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1000 Titel
  • Associations of Whole Blood n-3 and n-6 Polyunsaturated Fatty Acids with Blood Pressure in Children and Adolescents – Results from the IDEFICS/I.Family Cohort
1000 Autor/in
  1. Wolters, Maike |
  2. Pala, Valeria |
  3. Russo, Paola |
  4. Risé, Patrizia |
  5. Moreno, Luis A |
  6. De Henauw, Stefaan |
  7. Mehlig, Kirsten |
  8. Veidebaum, Toomas |
  9. Molnár, Denés |
  10. Tornaritis, Michael |
  11. Galli, Claudio |
  12. Börnhorst, Claudia |
  13. Ahrens, Wolfgang |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-11-02
1000 Erschienen in
1000 Quellenangabe
  • 11(11): e0165981
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pone.0165981 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091790/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Polyunsaturated n-3 and n-6 polyunsaturated fatty acids (PUFA) are precursors of biologically active metabolites that affect blood pressure (BP) regulation. This study investigated the association of n-3 and n-6 PUFA and BP in children and adolescents. METHODS: In a subsample of 1267 children aged 2–9 years at baseline of the European IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort whole blood fatty acids were measured by a validated gas chromatographic method. Systolic and diastolic BP was measured at baseline and after two and six years. Mixed-effects models were used to assess the associations between fatty acids at baseline and BP z-scores over time adjusting for relevant covariables. Models were further estimated stratified by sex and weight status. RESULTS: The baseline level of arachidonic acid was positively associated with subsequent systolic BP (β = 0.08, P = 0.002) and diastolic BP (β = 0.07, P<0.001). In thin/normal weight children, baseline alpha-linolenic (β = -1.13, P = 0.003) and eicosapentaenoic acid (β = -0.85, P = 0.003) levels were inversely related to baseline and also to subsequent systolic BP and alpha-linolenic acid to subsequent diastolic BP. In overweight/obese children, baseline eicosapentaenoic acid level was positively associated with baseline diastolic BP (β = 0.54, P = 0.005). CONCLUSIONS: Low blood arachidonic acid levels in the whole sample and high n-3 PUFA levels in thin/normal weight children are associated with lower and therefore healthier BP. The beneficial effects of high n-3 PUFA on BP were not observed in overweight/obese children, suggesting that they may have been overlaid by the unfavorable effects of excess weight.
1000 Sacherschließung
lokal Hypertension
lokal Body mass index
lokal Childhood obesity
lokal Blood pressure
lokal Children
lokal Food consumption
lokal Fatty acids
lokal Blood
1000 Fachgruppe
  1. Biologie |
  2. Medizin |
  3. Ernährungswissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/V29sdGVycywgTWFpa2U=|https://frl.publisso.de/adhoc/creator/UGFsYSwgVmFsZXJpYQ==|https://frl.publisso.de/adhoc/creator/UnVzc28sIFBhb2xh|https://frl.publisso.de/adhoc/creator/Umlzw6ksIFBhdHJpemlh|https://frl.publisso.de/adhoc/creator/TW9yZW5vLCBMdWlzIEE=|https://frl.publisso.de/adhoc/creator/RGUgSGVuYXV3LCBTdGVmYWFu|https://frl.publisso.de/adhoc/creator/TWVobGlnLCBLaXJzdGVu|https://frl.publisso.de/adhoc/creator/VmVpZGViYXVtLCBUb29tYXM=|https://frl.publisso.de/adhoc/creator/TW9sbsOhciwgRGVuw6lz|https://frl.publisso.de/adhoc/creator/VG9ybmFyaXRpcywgTWljaGFlbA==|https://frl.publisso.de/adhoc/creator/R2FsbGksIENsYXVkaW8=|https://frl.publisso.de/adhoc/creator/QsO2cm5ob3JzdCwgQ2xhdWRpYQ==|http://orcid.org/0000-0003-3777-570X
1000 Förderer
  1. European Commission |
1000 Fördernummer
  1. 016181 (FOOD); FP7 266044 (KBBE 2010-4)
1000 Förderprogramm
  1. Sixth RTD Framework Programme: IDEFICS study; Seventh RTD Framework Programme: I.Family study
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Commission |
    1000 Förderprogramm Sixth RTD Framework Programme: IDEFICS study; Seventh RTD Framework Programme: I.Family study
    1000 Fördernummer 016181 (FOOD); FP7 266044 (KBBE 2010-4)
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6406211.rdf
1000 Erstellt am 2018-01-08T15:12:42.762+0100
1000 Erstellt von 218
1000 beschreibt frl:6406211
1000 Bearbeitet von 240
1000 Zuletzt bearbeitet Mon Apr 16 10:30:26 CEST 2018
1000 Objekt bearb. Mon Apr 16 10:30:26 CEST 2018
1000 Vgl. frl:6406211
1000 Oai Id
  1. oai:frl.publisso.de:frl:6406211 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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