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1000 Titel
  • Longitudinal associations of lifestyle factors and weight status with insulin resistance (HOMA-IR) in preadolescent children: the large prospective cohort study IDEFICS
1000 Autor/in
  1. Peplies, Jenny |
  2. Börnhorst, Claudia |
  3. Günther, Kathrin |
  4. Fraterman, Arno |
  5. Russo, Paola |
  6. Veidebaum, Toomas |
  7. Tornaritis, Michael |
  8. De Henauw, Stefaan |
  9. Marild, Staffan |
  10. Molnar, Dénes |
  11. Moreno, Luis A |
  12. Ahrens, Wolfgang |
1000 Mitwirkende/r
  1. The IDEFICS consortium |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-09-02
1000 Erschienen in
1000 Quellenangabe
  • 13: 97
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12966-016-0424-4 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009569/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: This study investigates prospective associations of anthropometrical and lifestyle indices with insulin resistance (IR) in European children from the IDEFICS cohort. Insulin resistance (IR) is a growing concern in childhood obesity and a central aspect of the metabolic syndrome (MS). It most likely represents the link between obesity and type 2 diabetes. METHODS: This longitudinal study included 3348 preadolescent children aged 3 to 10.9 years from 8 European countries who were observed from 2007/2008 to 2009/2010. The main outcome measure in the present analysis is HOMA-IR (homeostasis model assessment as a common proxy indicator to quantify IR) at follow-up and in its longitudinal development. Anthropometrical measures and lifestyle indices, including objectively determined physical activity, were considered, among others factors, as determinants of IR. Prospective associations between IR at follow-up and anthropometrical and lifestyle indices were estimated by logistic regression models. RESULTS: Country-specific prevalence rates of IR in the IDEFICS cohort of European children showed a positive trend with weight category. Prospective multivariate analyses showed the strongest positive associations of IR with BMI z-score (OR = 2.6 for unit change from the mean, 95 % CI 2.1–3.1) and z-score of waist circumference (OR = 2.2 for unit change from the mean, 95 % CI 1.9–2.6), which were analysed in separate models, but also for sex (OR = 2.2 for girls vs. boys, 95 % CI 1.5–3.1 up to OR 2.5, 95 % CI 1.8–3.6 depending on the model), audio-visual media time (OR = 1.2 for an additional hour per day, 95 % CI 1.0–1.4 in both models) and an inverse association of objectively determined physical activity (OR = 0.5 for 3rd compared to 1st quartile, 95 % CI 0.3–0.9 in both models). A longitudinal reduction of HOMA-IR was accompanied with a parallel decline in BMI. CONCLUSIONS: This study is, to our knowledge, the first prospective study on IR in a preadolescent children’s population. It supports the common hypothesis that overweight and obesity are the main determinants of IR. Our data also indicate that physical inactivity and a sedentary lifestyle are likewise associated with the development of IR, independent of weight status. The promotion of physical activity should thus be considered as an equal option to dietary intervention for the treatment of IR in the paediatric practice.
1000 Sacherschließung
lokal HOMA-IR
lokal Obesity
lokal Physical activity
lokal Cohort study
lokal Accelerometer
lokal Insulin resistance
lokal Pre-pubertal children
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/UGVwbGllcywgSmVubnk=|https://frl.publisso.de/adhoc/creator/QsO2cm5ob3JzdCwgQ2xhdWRpYQ==|https://frl.publisso.de/adhoc/creator/R8O8bnRoZXIsIEthdGhyaW4=|https://frl.publisso.de/adhoc/creator/RnJhdGVybWFuLCBBcm5v|https://frl.publisso.de/adhoc/creator/UnVzc28sIFBhb2xh|https://frl.publisso.de/adhoc/creator/VmVpZGViYXVtLCBUb29tYXM=|https://frl.publisso.de/adhoc/creator/VG9ybmFyaXRpcywgTWljaGFlbA==|https://frl.publisso.de/adhoc/creator/RGUgSGVuYXV3LCBTdGVmYWFu|https://frl.publisso.de/adhoc/creator/TWFyaWxkLCBTdGFmZmFu|https://frl.publisso.de/adhoc/creator/TW9sbmFyLCBEw6luZXM=|https://frl.publisso.de/adhoc/creator/TW9yZW5vLCBMdWlzIEE=|http://orcid.org/0000-0003-3777-570X|https://frl.publisso.de/adhoc/contributor/VGhlIElERUZJQ1MgY29uc29ydGl1bQ==
1000 Förderer
  1. European Community |
1000 Fördernummer
  1. 016181 (FOOD)
1000 Förderprogramm
  1. Sixth RTD Framework Programme
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Community |
    1000 Förderprogramm Sixth RTD Framework Programme
    1000 Fördernummer 016181 (FOOD)
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6406225.rdf
1000 Erstellt am 2018-01-08T17:05:13.929+0100
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1000 Zuletzt bearbeitet Mon May 28 11:02:33 CEST 2018
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1000 Oai Id
  1. oai:frl.publisso.de:frl:6406225 |
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