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1000 Titel
  • Identification of T-Cell Antigens Specific for Latent Mycobacterium Tuberculosis Infection
1000 Autor/in
  1. Schuck, Sebastian D. |
  2. Mueller, Henrik |
  3. Kunitz, Frank |
  4. Neher, Albert |
  5. Hoffmann, Harald |
  6. Franken, Kees L.C.M. |
  7. Repsilber, Dirk |
  8. Ottenhoff, Tom H.M. |
  9. Kaufmann, Stefan H.E. |
  10. Jacobsen, Marc |
1000 Erscheinungsjahr 2009
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2009-05-18
1000 Erschienen in
1000 Quellenangabe
  • 4(5): e5590
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2009
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1371/journal.pone.0005590 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: T-cell responses against dormancy-, resuscitation-, and reactivation-associated antigens of Mycobacterium tuberculosis are candidate biomarkers of latent infection in humans. - METHODOLOGY/PRINCIPAL FINDINGS: We established an assay based on two rounds of in vitro restimulation and intracellular cytokine analysis that detects T-cell responses to antigens expressed during latent M. tuberculosis infection. Comparison between active pulmonary tuberculosis (TB) patients and healthy latently M. tuberculosis-infected donors (LTBI) revealed significantly higher T-cell responses against 7 of 35 tested M. tuberculosis latency-associated antigens in LTBI. Notably, T cells specific for Rv3407 were exclusively detected in LTBI but not in TB patients. The T-cell IFNγ response against Rv3407 in individual donors was the most influential factor in discrimination analysis that classified TB patients and LTBI with 83% accuracy using cross-validation. Rv3407 peptide pool stimulations revealed distinct candidate epitopes in four LTBI. - CONCLUSIONS: Our findings further support the hypothesis that the latency-associated antigens can be exploited as biomarkers for LTBI.
1000 Fachgruppe
  1. Medizin |
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