WeightNameValue
1000 Titel
  • Wilms' Tumor Protein Wt1 Is an Activator of the Anti-Müllerian Hormone Receptor Gene Amhr2
1000 Autor/in
  1. Klattig, Jürgen |
  2. Sierig, Ralph |
  3. Kruspe, Dagmar |
  4. Besenbeck, Birgit |
  5. Englert, Christoph |
1000 Erscheinungsjahr 2009
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2009-04-09
1000 Erschienen in
1000 Quellenangabe
  • 27(12): 4355-4364
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900060/ |
  • https://doi.org/10.1128/MCB.01780-06 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The Wilms' tumor protein Wt1 plays an essential role in mammalian urogenital development. WT1 mutations in humans lead to a variety of disorders, including Wilms' tumor, a pediatric kidney cancer, as well as Frasier and Denys-Drash syndromes. Phenotypic anomalies in Denys-Drash syndrome include pseudohermaphroditism and sex reversal in extreme cases. We have used cDNA microarray analyses on Wt1 knockout mice to identify Wt1-dependent genes involved in sexual development. The gene most dramatically affected by Wt1 inactivation was Amhr2, encoding the anti-Müllerian hormone (Amh) receptor 2. Amhr2 is an essential factor for the regression of the Müllerian duct in males, and mutations in AMHR2 lead to the persistent Müllerian duct syndrome, a rare form of male pseudohermaphroditism. Here we show that Wt1 and Amhr2 are coexpressed during urogenital development and that the Wt1 protein binds to the promoter region of the Amhr2 gene. Inactivation and overexpression of Wt1 in cell lines was followed by immediate changes of Amhr2 expression. The identification of Amhr2 as a Wt1 target provides new insights into the role of Wt1 in sexual differentiation and indicates, in addition to its function in early gonad development and sex determination, a novel function for Wt1, namely, in Müllerian duct regression.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/S2xhdHRpZywgSsO8cmdlbg==|https://frl.publisso.de/adhoc/creator/U2llcmlnLCBSYWxwaA==|https://frl.publisso.de/adhoc/creator/S3J1c3BlLCBEYWdtYXI=|https://frl.publisso.de/adhoc/creator/QmVzZW5iZWNrLCBCaXJnaXQ=|http://orcid.org/0000-0003-3284-8359
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft (DFG) |
1000 Fördernummer
  1. En280/6-1; En280/6-2
1000 Förderprogramm
  1. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer En280/6-1; En280/6-2
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6406417.rdf
1000 Erstellt am 2018-01-22T16:18:11.411+0100
1000 Erstellt von 218
1000 beschreibt frl:6406417
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet 2020-11-26T15:58:47.768+0100
1000 Objekt bearb. Thu Nov 26 15:58:47 CET 2020
1000 Vgl. frl:6406417
1000 Oai Id
  1. oai:frl.publisso.de:frl:6406417 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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