WeightNameValue
1000 Titel
  • Evidence for multiple alleles at the DGAT1 locus better explains a quantitative trait locus with major effect on milk fat content in cattle
1000 Autor/in
  1. Kühn, Christa |
  2. Thaller, Georg |
  3. Winter, Andreas |
  4. Bininda-Emonds, Olaf R. P. |
  5. Kaupe, Bernhard |
  6. Erhardt, Georg |
  7. Bennewitz, Jörn |
  8. Schwerin, Manfred |
  9. Fries, Ruedi |
1000 Erscheinungsjahr 2004
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2004-09-01
1000 Erschienen in
1000 Quellenangabe
  • 167(4): 1873–1881
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470998/ |
  • http://dx.doi.org/10.1534/genetics.103.022749 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • A quantitative trait locus (QTL) for milk fat percentage has been mapped consistently to the centromeric region of bovine chromosome 14 (BTA14). Two independent studies have identified the nonconservative mutation K232A in the acylCoA-diacylglycerol-acyltransferase 1 (DGAT1) gene as likely to be causal for the observed variation. Here we provide evidence for additional genetic variability at the same QTL that is associated with milk fat percentage variation within the German Holstein population. Namely, we show that alleles of the DGAT1 promoter derived from the variable number of tandem repeat (VNTR) polymorphism are associated with milk fat content in animals homozygous for the allele 232A at DGAT1. Our results present another example for more than two trait-associated alleles being involved in a major gene effect on a quantitative trait. The segregation of multiple alleles affecting milk production traits at the QTL on BTA14 has to be considered whenever marker-assisted selection programs are implemented in dairy cattle. Due to the presence of a potential transcription factor binding site in the 18mer element of the VNTR, the variation in the number of tandem repeats of the 18mer element might be causal for the variability in the transcription level of the DGAT1 gene.
1000 Fachgruppe
  1. Agrarwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/S8O8aG4sIENocmlzdGE=|https://frl.publisso.de/adhoc/creator/VGhhbGxlciwgR2Vvcmc=|https://frl.publisso.de/adhoc/creator/V2ludGVyLCBBbmRyZWFz|https://frl.publisso.de/adhoc/creator/QmluaW5kYS1FbW9uZHMsIE9sYWYgUi4gUC4=|https://frl.publisso.de/adhoc/creator/S2F1cGUsIEJlcm5oYXJk|https://frl.publisso.de/adhoc/creator/RXJoYXJkdCwgR2Vvcmc=|https://frl.publisso.de/adhoc/creator/QmVubmV3aXR6LCBKw7Zybg==|https://frl.publisso.de/adhoc/creator/U2Nod2VyaW4sIE1hbmZyZWQ=|https://frl.publisso.de/adhoc/creator/RnJpZXMsIFJ1ZWRp
1000 Förderer
  1. Federal Ministry of Education and Research |
  2. German Cattle Breeders Federation |
  3. German artificial insemination stations |
1000 Fördernummer
  1. project 0311020A
  2. -
  3. -
1000 Förderprogramm
  1. -
  2. -
  3. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Federal Ministry of Education and Research |
    1000 Förderprogramm -
    1000 Fördernummer project 0311020A
  2. 1000 joinedFunding-child
    1000 Förderer German Cattle Breeders Federation |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer German artificial insemination stations |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6406445.rdf
1000 Erstellt am 2018-01-24T12:49:02.062+0100
1000 Erstellt von 22
1000 beschreibt frl:6406445
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Wed May 16 10:16:36 CEST 2018
1000 Objekt bearb. Wed May 16 10:16:36 CEST 2018
1000 Vgl. frl:6406445
1000 Oai Id
  1. oai:frl.publisso.de:frl:6406445 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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