Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement

  1. Solecki, Roland
  2. Kortenkamp, Andreas
  3. Bergman, Åke
  4. Chahoud, Ibrahim
  5. Dietrich, Daniel
  6. Greim, Helmut
  7. Håkansson, Helen
  8. Hass, Ulla
  9. Husoy, Trine
  10. Jacobs, Miriam
  11. Jobling, Susan
  12. Mantovani, Alberto
  13. Marx-Stoelting, Philip
  14. Piersma, Aldert
  15. Ritz, Vera
  16. Slama, Remy
  17. Stahlmann, Ralf
  18. van den Berg, Martin
  19. Zoeller, R. Thomas
  20. Boobis, Alan R.
  21. Degen, Gisela H.

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WeightNameValue
1000 Titel
  • Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement
1000 Autor/in
  1. Solecki, Roland |
  2. Kortenkamp, Andreas |
  3. Bergman, Åke |
  4. Chahoud, Ibrahim |
  5. Dietrich, Daniel |
  6. Greim, Helmut |
  7. Håkansson, Helen |
  8. Hass, Ulla |
  9. Husoy, Trine |
  10. Jacobs, Miriam |
  11. Jobling, Susan |
  12. Mantovani, Alberto |
  13. Marx-Stoelting, Philip |
  14. Piersma, Aldert |
  15. Ritz, Vera |
  16. Slama, Remy |
  17. Stahlmann, Ralf |
  18. van den Berg, Martin |
  19. Zoeller, R. Thomas |
  20. Boobis, Alan R. |
  21. Degen, Gisela H. |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-10-06
1000 Erschienen in
1000 Quellenangabe
  • 91(2):1001-1006
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00204-016-1866-9 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306068/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Endocrine disruption is a specific form of toxicity, where natural and/or anthropogenic chemicals, known as “endocrine disruptors” (EDs), trigger adverse health effects by disrupting the endogenous hormone system. There is need to harmonize guidance on the regulation of EDs, but this has been hampered by what appeared as a lack of consensus among scientists. This publication provides summary information about a consensus reached by a group of world-leading scientists that can serve as the basis for the development of ED criteria in relevant EU legislation. Twenty-three international scientists from different disciplines discussed principles and open questions on ED identification as outlined in a draft consensus paper at an expert meeting hosted by the German Federal Institute for Risk Assessment (BfR) in Berlin, Germany on 11–12 April 2016. Participants reached a consensus regarding scientific principles for the identification of EDs. The paper discusses the consensus reached on background, definition of an ED and related concepts, sources of uncertainty, scientific principles important for ED identification, and research needs. It highlights the difficulty in retrospectively reconstructing ED exposure, insufficient range of validated test systems for EDs, and some issues impacting on the evaluation of the risk from EDs, such as non-monotonic dose–response and thresholds, modes of action, and exposure assessment. This report provides the consensus statement on EDs agreed among all participating scientists. The meeting facilitated a productive debate and reduced a number of differences in views. It is expected that the consensus reached will serve as an important basis for the development of regulatory ED criteria.
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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  1. Federal Institute for Risk Assessment
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1000 Erstellt am 2018-01-24T13:15:15.761+0100
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