WeightNameValue
1000 Titel
  • Targeted Inactivation of the Tetraspanin CD37 Impairs T-Cell-Dependent B-Cell Response under Suboptimal Costimulatory Conditions
1000 Autor/in
  1. Knobeloch, Klaus-Peter |
  2. Wright, Mark D. |
  3. Ochsenbein, Adrian F. |
  4. Liesenfeld, Oliver |
  5. Löhler, Jürgen |
  6. Zinkernagel, Rolf M. |
  7. Horak, Ivan |
  8. Orinska, Zane |
1000 Erscheinungsjahr 2000
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2000-08
1000 Erschienen in
1000 Quellenangabe
  • 20(15): 5363-5369
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85988/ |
  • https://doi.org/10.1128/MCB.20.15.5363-5369.2000 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • CD37 is a membrane protein of the tetraspanin superfamily, which includes CD9, CD53, CD63, CD81, and CD82. Many of these molecules are expressed on leukocytes and have been implicated in signal transduction, cell-cell interactions, and cellular activation and development. We generated and analyzed mice deficient for CD37. Despite the high expression of CD37 on cells of the immune system, no changes in development and cellular composition of lymphoid organs were observed in mice lacking CD37. Analyses of humoral immune responses revealed a reduced level of immunoglobulin G1 (IgG1) in the sera of nonimmunized mice and an alteration of responses to T-cell-dependent antigens. Antibody responses to model antigen administered in the absence of adjuvant and to viral infections were generally poor in CD37-deficient mice. These poor antibody responses could be overcome by the immunization of antigen together with adjuvant. These results suggest a role for CD37 in T-cell–B-cell interactions which manifests itself under suboptimal costimulatory conditions.
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/S25vYmVsb2NoLCBLbGF1cy1QZXRlcg==|https://frl.publisso.de/adhoc/creator/V3JpZ2h0LCBNYXJrIEQu|https://frl.publisso.de/adhoc/creator/T2Noc2VuYmVpbiwgQWRyaWFuIEYu|https://frl.publisso.de/adhoc/creator/TGllc2VuZmVsZCwgT2xpdmVy|https://frl.publisso.de/adhoc/creator/TMO2aGxlciwgSsO8cmdlbg==|https://frl.publisso.de/adhoc/creator/Wmlua2VybmFnZWwsIFJvbGYgTS4=|https://frl.publisso.de/adhoc/creator/SG9yYWssIEl2YW4=|https://frl.publisso.de/adhoc/creator/T3JpbnNrYSwgWmFuZQ==
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft (DFG) |
1000 Fördernummer
  1. Ho493/11
1000 Förderprogramm
  1. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer Ho493/11
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6406608.rdf
1000 Erstellt am 2018-02-01T16:31:01.725+0100
1000 Erstellt von 218
1000 beschreibt frl:6406608
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 21:19:00 CET 2020
1000 Objekt bearb. Wed Jun 20 13:25:38 CEST 2018
1000 Vgl. frl:6406608
1000 Oai Id
  1. oai:frl.publisso.de:frl:6406608 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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