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Cozzolino-et-al_2017_Urinary volatile organic compounds in overweight compared to normal-weight children.pdf 1,75MB
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1000 Titel
  • Urinary volatile organic compounds in overweight compared to normal-weight children: results from the Italian I.Family cohort
1000 Autor/in
  1. Cozzolino, Rosaria |
  2. De Giulio, Beatrice |
  3. Marena, Pasquale |
  4. Martignetti, Antonella |
  5. Günther, Kathrin |
  6. Lauria, Fabio |
  7. Russo, Paola |
  8. Stocchero, Matteo |
  9. Siani, Alfonso |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-11-05
1000 Erschienen in
1000 Quellenangabe
  • 7: 15636
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1038/s41598-017-15957-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688068/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Accumulating evidence shows that urinary volatile organic compounds (VOCs) could be perturbed in many physiological and pathological states, including several diseases and different dietary exposures. Few studies investigated the urinary metabolic signature associated to excess body weight and obesity in adult populations, while a different VOCs profile was found in exhaled breath in obese as compared to lean children. Aim of this study was to evaluate the VOCs profile in the urine of 21 overweight/obese (OW/Ob) and 28 normal-weight (NW) children belonging to the Italian cohort of the I. Family study. Urine samples were analysed by Solid Phase Micro-Extraction (SPME) GC-MS under both acidic and alkaline conditions, in order to profile a wider range of urinary volatiles with different physicochemical properties. Multivariate statistics techniques were applied to bioanalytical data to visualize clusters of cases and detect the VOCs able to differentiate OW/Ob from NW children. Under alkaline conditions, fourteen VOCs were identified, distinguishing OW/Ob from NW children. Our results suggest that VOCs signatures differ between OW/Ob and NW children. However, the biological and pathophysiological meaning of the observed differences needs to be elucidated, in order to better understand the potential of urinary VOCs as early metabolic biomarkers of obesity.
1000 Sacherschließung
lokal Prognostic markers
lokal Metabolomics
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/Q296em9saW5vLCBSb3Nhcmlh|https://frl.publisso.de/adhoc/creator/RGUgR2l1bGlvLCBCZWF0cmljZQ==|https://frl.publisso.de/adhoc/creator/TWFyZW5hLCBQYXNxdWFsZQ==|https://frl.publisso.de/adhoc/creator/TWFydGlnbmV0dGksIEFudG9uZWxsYQ==|https://frl.publisso.de/adhoc/creator/R8O8bnRoZXIsIEthdGhyaW4=|https://frl.publisso.de/adhoc/creator/TGF1cmlhLCBGYWJpbw==|https://frl.publisso.de/adhoc/creator/UnVzc28sIFBhb2xh|https://frl.publisso.de/adhoc/creator/U3RvY2NoZXJvLCBNYXR0ZW8=|https://frl.publisso.de/adhoc/creator/U2lhbmksIEFsZm9uc28=
1000 Förderer
  1. European Community |
1000 Fördernummer
  1. 266044
1000 Förderprogramm
  1. Seventh RTD Framework Programme
1000 Dateien
  1. Urinary volatile organic compounds in overweight compared to normal-weight children
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Community |
    1000 Förderprogramm Seventh RTD Framework Programme
    1000 Fördernummer 266044
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6406723.rdf
1000 Erstellt am 2018-02-16T14:43:07.411+0100
1000 Erstellt von 266
1000 beschreibt frl:6406723
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jun 28 11:02:35 CEST 2018
1000 Objekt bearb. Thu Jun 28 11:02:34 CEST 2018
1000 Vgl. frl:6406723
1000 Oai Id
  1. oai:frl.publisso.de:frl:6406723 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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