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1000 Titel
  • Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress
1000 Autor/in
  1. Binsch, C. |
  2. Jelenik, T. |
  3. Pfitzer, A. |
  4. Dille, M. |
  5. Müller-Lühlhoff, S. |
  6. Hartwig, S. |
  7. Karpinski, S. |
  8. Lehr, S. |
  9. Kabra, D.G. |
  10. Chadt, A. |
  11. Roden, M. |
  12. Al-Hasani, H. |
  13. Castañeda, T.R. |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-08-25
1000 Erschienen in
1000 Quellenangabe
  • 6(11):1443-1453
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.molmet.2017.08.008 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681242/ |
1000 Ergänzendes Material
  • https://www.sciencedirect.com/science/article/pii/S2212877817305422?via%3Dihub#appsec2 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • OBJECTIVE: Ribosomal protein S6 Kinase-1 (S6K1) has been linked to resistance exercise-mediated improvements in glycemia. We hypothesized that S6K1 may also play a role in regulating glycemic control in response to endurance exercise training. METHODS: S6k1-knockout (S6K1KO) and WT mice on a 60 cal% high-fat diet were trained for 4 weeks on treadmills, metabolically phenotyped, and compared to sedentary controls. RESULTS: WT mice showed improved glucose tolerance after training. In contrast, S6K1KO mice displayed equally high glucose tolerance already in the sedentary state with no further improvement after training. Similarly, training decreased mitochondrial ROS production in skeletal muscle of WT mice, whereas ROS levels were already low in the sedentary S6K1KO mice with no further decrease after training. Nevertheless, trained S6K1KO mice displayed an increased running capacity compared to trained WT mice, as well as substantially reduced triglyceride contents in liver and skeletal muscle. The improvements in glucose handling and running endurance in S6K1KO mice were associated with markedly increased ketogenesis and a higher respiratory exchange ratio. CONCLUSIONS: In high-fat fed mice, loss of S6K1 mimics endurance exercise training by reducing mitochondrial ROS production and upregulating oxidative utilization of ketone bodies. Pharmacological targeting of S6K1 may improve the outcome of exercise-based interventions in obesity and diabetes.
1000 Sacherschließung
lokal Glycemic control
lokal Reactive oxidative species
lokal Exercise
lokal Metabolic phenotyping
lokal S6K1
1000 Fachgruppe
  1. Biologie |
  2. Ernährungswissenschaften |
  3. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/Qmluc2NoLCBDLg==|https://frl.publisso.de/adhoc/creator/SmVsZW5paywgVC4=|https://frl.publisso.de/adhoc/creator/UGZpdHplciwgQS4=|https://frl.publisso.de/adhoc/creator/RGlsbGUsIE0u|https://frl.publisso.de/adhoc/creator/TcO8bGxlci1Mw7xobGhvZmYsIFMu|https://frl.publisso.de/adhoc/creator/SGFydHdpZywgUy4=|https://frl.publisso.de/adhoc/creator/S2FycGluc2tpLCBTLg==|https://frl.publisso.de/adhoc/creator/TGVociwgUy4=|https://frl.publisso.de/adhoc/creator/S2FicmEsIEQuRy4=|https://frl.publisso.de/adhoc/creator/Q2hhZHQsIEEu|https://frl.publisso.de/adhoc/creator/Um9kZW4sIE0u|https://frl.publisso.de/adhoc/creator/QWwtSGFzYW5pLCBILg==|https://frl.publisso.de/adhoc/creator/Q2FzdGHDsWVkYSwgVC5SLg==
1000 Label
1000 Förderer
  1. Ministry of Innovation, Science and Research of the State of North Rhine-Westphalia (MIWF NRW)
  2. German Federal Ministry of Health (BMG)
  3. Deutsche Forschungsgemeinschaft
  4. German Academic Exchange Service (DAAD)
1000 Fördernummer
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  3. -
  4. -
1000 Förderprogramm
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  2. -
  3. SFB1116
  4. -
1000 Dateien
1000 Objektart article
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1000 @id frl:6406851.rdf
1000 Erstellt am 2018-02-27T14:02:15.597+0100
1000 Erstellt von 25
1000 beschreibt frl:6406851
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet 2020-01-30T16:27:11.151+0100
1000 Objekt bearb. Mon Apr 30 13:09:02 CEST 2018
1000 Vgl. frl:6406851
1000 Oai Id
  1. oai:frl.publisso.de:frl:6406851 |
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