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1000 Titel
  • Serum levels of interleukin-22, cardiometabolic risk factors and incident type 2 diabetes: KORA F4/FF4 study
1000 Autor/in
  1. Herder, Christian |
  2. Kannenberg, Julia M. |
  3. Carstensen-Kirberg, Maren |
  4. Huth, Cornelia |
  5. Meisinger, Christa |
  6. Koenig, Wolfgang |
  7. Peters, Annette |
  8. Rathmann, Wolfgang |
  9. Roden, Michael |
  10. Thorand, Barbara |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-01-31
1000 Erschienen in
1000 Quellenangabe
  • 16:17
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12933-017-0498-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282888/ |
1000 Ergänzendes Material
  • https://cardiab.biomedcentral.com/articles/10.1186/s12933-017-0498-6#Declarations |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • AIMS: Interleukin-22 (IL-22) has beneficial effects on body weight, insulin resistance and inflammation in different mouse models, but its relevance for the development of type 2 diabetes in humans is unknown. We aimed to identify correlates of serum IL-22 levels and to test the hypothesis that higher IL-22 levels are associated with lower diabetes incidence. METHODS: Cross-sectional associations between serum IL-22, cardiometabolic risk factors and glucose tolerance status were investigated in 1107 persons of the population-based KORA F4 study. The prospective association between serum IL-22 and incident type 2 diabetes was assessed in 504 initially non-diabetic study participants in both the KORA F4 study and its 7-year follow-up examination KORA FF4, 76 of whom developed diabetes. RESULTS: Male sex, current smoking, lower HDL cholesterol, lower estimated glomerular filtration rate and higher serum interleukin-1 receptor antagonist were associated with higher IL-22 levels after adjustment for confounders (all P < 0.05). Serum IL-22 showed no associations with glucose tolerance status, prediabetes or type 2 diabetes. Baseline serum IL-22 levels (median, 25th/75th percentiles) for incident type 2 diabetes cases and non-cases were 6.28 (1.95; 12.35) and 6.45 (1.95; 11.80) pg/ml, respectively (age and sex-adjusted P = 0.744). The age and sex-adjusted OR (95% CI) per doubling of IL-22 for incident type 2 diabetes of 1.02 (0.85; 1.23) was almost unchanged after consideration of further confounders. CONCLUSIONS: High serum levels of IL-22 were positively rather than inversely associated with several cardiometabolic risk factors. However, these associations did not translate into an increased risk for type 2 diabetes. Thus, our data argue against the utility of IL-22 as biomarker for prevalent or incident type 2 diabetes in humans, but identify potential determinants of IL-22 levels which merits further research in the context of cardiovascular diseases.
1000 Sacherschließung
lokal Type 2 diabetes
lokal Interleukin-22
lokal Cohort study
lokal Cytokine
lokal Cardiometabolic risk
lokal Inflammation
1000 Fachgruppe
  1. Biologie |
  2. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0002-2050-093X|https://frl.publisso.de/adhoc/creator/S2FubmVuYmVyZywgSnVsaWEgTS4=|https://frl.publisso.de/adhoc/creator/Q2Fyc3RlbnNlbi1LaXJiZXJnLCBNYXJlbg==|https://frl.publisso.de/adhoc/creator/SHV0aCwgQ29ybmVsaWE=|https://frl.publisso.de/adhoc/creator/TWVpc2luZ2VyLCBDaHJpc3Rh|https://frl.publisso.de/adhoc/creator/S29lbmlnLCBXb2xmZ2FuZw==|https://frl.publisso.de/adhoc/creator/UGV0ZXJzLCBBbm5ldHRl|http://d-nb.info/gnd/112013597|http://d-nb.info/gnd/130812773|https://frl.publisso.de/adhoc/creator/VGhvcmFuZCwgQmFyYmFyYQ==
1000 Label
1000 Förderer
  1. Helmholtz Zentrum München – German Research Center for Environmental Health |
  2. German Federal Ministry of Education and Research (BMBF) |
  3. State of Bavaria |
  4. Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universität |
  5. Ministry of Science and Research of the State of North Rhine-Westphalia (MIWF NRW) |
  6. German Federal Ministry of Health (BMG) |
  7. German Diabetes Foundation (DDS) |
  8. German Research Foundation (DFG) |
  9. German Center for Diabetes Research (DZD) |
1000 Fördernummer
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  6. -
  7. -
  8. RA 459/3-1
  9. -
1000 Förderprogramm
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  3. -
  4. LMUinnovativ
  5. -
  6. -
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1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Helmholtz Zentrum München – German Research Center for Environmental Health |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Education and Research (BMBF) |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer State of Bavaria |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universität |
    1000 Förderprogramm LMUinnovativ
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Ministry of Science and Research of the State of North Rhine-Westphalia (MIWF NRW) |
    1000 Förderprogramm -
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Health (BMG) |
    1000 Förderprogramm -
    1000 Fördernummer -
  7. 1000 joinedFunding-child
    1000 Förderer German Diabetes Foundation (DDS) |
    1000 Förderprogramm -
    1000 Fördernummer -
  8. 1000 joinedFunding-child
    1000 Förderer German Research Foundation (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer RA 459/3-1
  9. 1000 joinedFunding-child
    1000 Förderer German Center for Diabetes Research (DZD) |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6406920.rdf
1000 Erstellt am 2018-03-01T08:39:35.763+0100
1000 Erstellt von 25
1000 beschreibt frl:6406920
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Jan 30 21:19:25 CET 2020
1000 Objekt bearb. Fri Jul 27 12:05:19 CEST 2018
1000 Vgl. frl:6406920
1000 Oai Id
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1000 Sichtbarkeit Metadaten public
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