Metabolite profiling in identifying metabolic Biomarkers in older people with late-onset type 2 Diabetes mellitus

  1. Tam, Zhi Yang
  2. Ng, Sean Pin
  3. Tan, Ling Qiao
  4. Lin, Chih-Hsien
  5. Rothenbacher, Dietrich
  6. Klenk, Jochen
  7. Böhm, Bernhard O.
  8. Kiat, Kelvin Goh Kau
  9. Suwanchaikasem, Pipob
  10. Tipthara, Pornpimol
  11. Yang, Song Yi
  12. Becker, Thomas
  13. Stingl, Julia ORCID logo
  14. König, Wolfgang
  15. Riepe, Matthias W.
  16. Peter, Richard
  17. Geiger, Hartmut
  18. Ludolph, Albert C.
  19. Arnim, Christine von
  20. Nagel, Gabriele
  21. Weinmayr, Gudrun
  22. Rapp, Kilian
  23. Denkinger, Michael D.
  24. Dallmeier, Dhayana
  25. Steinacker, Jürgen M.
  26. Laszlo, Roman

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WeightNameValue
1000 Titel
  • Metabolite profiling in identifying metabolic Biomarkers in older people with late-onset type 2 Diabetes mellitus
1000 Autor/in
  1. Tam, Zhi Yang |
  2. Ng, Sean Pin |
  3. Tan, Ling Qiao |
  4. Lin, Chih-Hsien |
  5. Rothenbacher, Dietrich |
  6. Klenk, Jochen |
  7. Böhm, Bernhard O. |
  8. Kiat, Kelvin Goh Kau |
  9. Suwanchaikasem, Pipob |
  10. Tipthara, Pornpimol |
  11. Yang, Song Yi |
  12. Becker, Thomas |
  13. Stingl, Julia |
  14. König, Wolfgang |
  15. Riepe, Matthias W. |
  16. Peter, Richard |
  17. Geiger, Hartmut |
  18. Ludolph, Albert C. |
  19. Arnim, Christine von |
  20. Nagel, Gabriele |
  21. Weinmayr, Gudrun |
  22. Rapp, Kilian |
  23. Denkinger, Michael D. |
  24. Dallmeier, Dhayana |
  25. Steinacker, Jürgen M. |
  26. Laszlo, Roman |
1000 Erscheinungsjahr 2017
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-06-29
1000 Erschienen in
1000 Quellenangabe
  • 7(2017):4392
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • http://doi.org/10.1038/s41598-017-01735-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491522/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41598-017-01735-y#Sec16 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Regulation of blood glucose requires precise coordination between different endocrine systems and multiple organs. Type 2 diabetes mellitus (T2D) arises from a dysregulated response to elevated glucose levels in the circulation. Globally, the prevalence of T2D has increased dramatically in all age groups. T2D in older adults is associated with higher mortality and reduced functional status, leading to higher rate of institutionalization. Despite the potential healthcare challenges associated with the presence of T2D in the elderly, the pathogenesis and phenotype of late-onset T2D is not well studied. Here we applied untargeted metabolite profiling of urine samples from people with and without late-onset T2D using ultra-performance liquid-chromatography mass-spectrometry (UPLC-MS) to identify urinary biomarkers for late-onset T2D in the elderly. Statistical modeling of measurements and thorough validation of structural assignment using liquid chromatography tandem mass-spectrometry (LC-MS/MS) have led to the identification of metabolite biomarkers associated with late-onset T2D. Lower levels of phenylalanine, acetylhistidine, and cyclic adenosine monophosphate (cAMP) were found in urine samples of T2D subjects validated with commercial standards. Elevated levels of 5′-methylthioadenosine (MTA), which previously has only been implicated in animal model of diabetes, was found in urine of older people with T2D.
1000 Sacherschließung
lokal Type 2 diabetes
lokal Metabolomics
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://d-nb.info/gnd/111656369X|https://frl.publisso.de/adhoc/creator/TmcsIFNlYW4gUGluIA==|https://frl.publisso.de/adhoc/creator/VGFuLCBMaW5nIFFpYW8=|https://frl.publisso.de/adhoc/creator/TGluLCBDaGloLUhzaWVu|http://d-nb.info/gnd/1022161520|http://d-nb.info/gnd/138866295|http://d-nb.info/gnd/110747860|https://frl.publisso.de/adhoc/creator/S2lhdCwgS2VsdmluIEdvaCBLYXUg|https://frl.publisso.de/adhoc/creator/U3V3YW5jaGFpa2FzZW0sIFBpcG9iIA==|https://frl.publisso.de/adhoc/creator/VGlwdGhhcmEsIFBvcm5waW1vbCA=|https://frl.publisso.de/adhoc/creator/WWFuZywgU29uZyBZaSA=|http://d-nb.info/gnd/133404900|http://orcid.org/0000-0002-1566-8156|https://frl.publisso.de/adhoc/creator/S8O2bmlnLCBXb2xmZ2FuZw==|http://d-nb.info/gnd/187944075|http://d-nb.info/gnd/132858681|https://frl.publisso.de/adhoc/creator/R2VpZ2VyLCBIYXJ0bXV0|http://d-nb.info/gnd/1081317531|http://d-nb.info/gnd/115687270|http://d-nb.info/gnd/135882036|https://frl.publisso.de/adhoc/creator/V2Vpbm1heXIsIEd1ZHJ1bg==|http://d-nb.info/gnd/114041989|http://d-nb.info/gnd/129036609|https://frl.publisso.de/adhoc/creator/RGFsbG1laWVyLCBEaGF5YW5h|http://d-nb.info/gnd/133888797|http://d-nb.info/gnd/129113174
1000 Label
1000 Förderer
  1. Ministry of Science, Research and Arts, state of Baden-Wuerttemberg, Germany
  2. Robert Bosch Foundation, Stuttgart, Germany
  3. LKC School of Medicine, Nanyang Technological University, Singapore
  4. Deutsche Forschungsgemeinschaft (DFG)
  5. Lee Kong Chian School of Medicine (LKCMedicine)
  6. Singapore Centre on Environmental Life Sciences Engineering (SCELSE)
  7. School of Biological Sciences (SBS)
  8. Nanyang Technological University, Singapore
1000 Fördernummer
  1. -
  2. -
  3. -
  4. DFG GRK 1041
  5. -
  6. -
  7. -
  8. -
1000 Förderprogramm
  1. -
  2. "Forschungskolleg Geriatrie”
  3. -
  4. -
  5. -
  6. -
  7. -
  8. -
1000 Dateien
1000 Objektart article
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1000 @id frl:6407092.rdf
1000 Erstellt am 2018-03-13T13:01:26.800+0100
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1000 Bearbeitet von 122
1000 Zuletzt bearbeitet 2020-01-30T18:50:01.653+0100
1000 Objekt bearb. Wed Mar 14 11:01:54 CET 2018
1000 Vgl. frl:6407092
1000 Oai Id
  1. oai:frl.publisso.de:frl:6407092 |
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