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1000 Titel
  • Percentiles of fasting serum insulin, glucose, HbA1c and HOMA-IR in pre-pubertal normal weight European children from the IDEFICS cohort
1000 Autor/in
  1. Peplies, Jenny |
  2. Jimenez-Pavon, David |
  3. Savva, Savvas C. |
  4. Buck, Christoph |
  5. Günther, Kathrin |
  6. Fraterman, Arno |
  7. Russo, Paola |
  8. Iacoviello, Licia |
  9. Veidebaum, Toomas |
  10. Tornaritis, Michael |
  11. De Henauw, Stefaan |
  12. Marild, Staffan |
  13. Molnar, Dénes |
  14. Moreno, Luis A. |
  15. Ahrens, Wolfgang |
1000 Mitwirkende/r
  1. The IDEFICS consortium |
1000 Erscheinungsjahr 2014
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2014-09-15
1000 Erschienen in
1000 Quellenangabe
  • 38: S39-S47
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2014
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1038/ijo.2014.134 |
1000 Ergänzendes Material
  • https://www.nature.com/articles/ijo2014134#supplementary-information |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • OBJECTIVES: The aim of this study is to present age- and sex-specific reference values of insulin, glucose, glycosylated haemoglobin (HbA1c) and the homeostasis model assessment to quantify insulin resistance (HOMA-IR) for pre-pubertal children. METHODS: The reference population consists of 7074 normal weight 3- to 10.9-year-old pre-pubertal children from eight European countries who participated in at least one wave of the IDEFICS (‘identification and prevention of dietary- and lifestyle-induced health effects in children and infants’) surveys (2007–2010) and for whom standardised laboratory measurements were obtained. Percentile curves of insulin (measured by an electrochemiluminescence immunoassay), glucose, HbA1c and HOMA-IR were calculated as a function of age stratified by sex using the general additive model for location scale and shape (GAMLSS) method. RESULTS: Levels of insulin, fasting glucose and HOMA-IR continuously show an increasing trend with age, whereas HbA1c shows an upward trend only beyond the age of 8 years. Insulin and HOMA-IR values are higher in girls of all age groups, whereas glucose values are slightly higher in boys. Median serum levels of insulin range from 17.4 and 13.2 pmol l−1 in 3–<3.5-year-old girls and boys, respectively, to 53.5 and 43.0 pmol l−1 in 10.5–<11-year-old girls and boys. Median values of glucose are 4.3 and 4.5 mmol l−1 in the youngest age group and 49.3 and 50.6 mmol l−1 in the oldest girls and boys. For HOMA-IR, median values range from 0.5 and 0.4 in 3–<3.5-year-old girls and boys to 1.7 and 1.4 in 10.5–<11-year-old girls and boys, respectively. CONCLUSIONS: Our study provides the first standardised reference values for an international European children’s population and provides the, up to now, largest data set of healthy pre-pubertal children to model reference percentiles for markers of insulin resistance. Our cohort shows higher values of Hb1Ac as compared with a single Swedish study while our percentiles for the other glucose metabolic markers are in good accordance with previous studies.
1000 Sacherschließung
lokal Epidemiology
lokal Metabolic disorders
lokal Paediatrics
1000 Fachgruppe
  1. Medizin |
  2. Gesundheitswesen |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/UGVwbGllcywgSmVubnk=|https://frl.publisso.de/adhoc/creator/SmltZW5lei1QYXZvbiwgRGF2aWQ=|https://frl.publisso.de/adhoc/creator/U2F2dmEsIFNhdnZhcyBDLg==|https://frl.publisso.de/adhoc/creator/QnVjaywgQ2hyaXN0b3Bo|https://frl.publisso.de/adhoc/creator/R8O8bnRoZXIsIEthdGhyaW4=|https://frl.publisso.de/adhoc/creator/RnJhdGVybWFuLCBBcm5v|https://frl.publisso.de/adhoc/creator/UnVzc28sIFBhb2xh|https://frl.publisso.de/adhoc/creator/SWFjb3ZpZWxsbywgTGljaWE=|https://frl.publisso.de/adhoc/creator/VmVpZGViYXVtLCBUb29tYXM=|https://frl.publisso.de/adhoc/creator/VG9ybmFyaXRpcywgTWljaGFlbA==|https://frl.publisso.de/adhoc/creator/RGUgSGVuYXV3LCBTdGVmYWFu|https://frl.publisso.de/adhoc/creator/TWFyaWxkLCBTdGFmZmFu|https://frl.publisso.de/adhoc/creator/TW9sbmFyLCBEw6luZXM=|https://frl.publisso.de/adhoc/creator/TW9yZW5vLCBMdWlzIEEu|http://orcid.org/0000-0003-3777-570X|https://frl.publisso.de/adhoc/corporateBody/VGhlIElERUZJQ1MgY29uc29ydGl1bQ==
1000 Förderer
  1. European Community |
  2. Volkswagen Foundation |
1000 Fördernummer
  1. 016181 (FOOD)
  2. -
1000 Förderprogramm
  1. Sixth Framework Programme
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Community |
    1000 Förderprogramm Sixth Framework Programme
    1000 Fördernummer 016181 (FOOD)
  2. 1000 joinedFunding-child
    1000 Förderer Volkswagen Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6407166.rdf
1000 Erstellt am 2018-03-16T12:17:16.432+0100
1000 Erstellt von 266
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1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Fri Mar 16 13:51:04 CET 2018
1000 Objekt bearb. Fri Mar 16 12:18:01 CET 2018
1000 Vgl. frl:6407166
1000 Oai Id
  1. oai:frl.publisso.de:frl:6407166 |
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