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1000 Titel
  • R2d2 Drives Selfish Sweeps in the House Mouse
1000 Autor/in
  1. Didion, John P. |
  2. Morgan, Andrew P. |
  3. Yadgary, Liran |
  4. Bell, Timothy A. |
  5. McMullan, Rachel C. |
  6. Ortiz de Solorzano, Lydia |
  7. Britton-Davidian, Janice |
  8. Bult, Carol J. |
  9. Campbell, Karl J. |
  10. Castiglia, Riccardo |
  11. Ching, Yung-Hao |
  12. Chunco, Amanda J. |
  13. Crowley, James J. |
  14. Chesler, Elissa J. |
  15. Förster, Daniel W. |
  16. French, John E. |
  17. Gabriel, Sofia I. |
  18. Gatti, Daniel M. |
  19. Garland, Jr ,Theodore |
  20. Giagia-Athanasopoulou, Eva B. |
  21. Giménez, Mabel D. |
  22. Grize, Sofia A. |
  23. Gündüz, İslam |
  24. Holmes, Andrew |
  25. Hauffe, Heidi C. |
  26. Herman, Jeremy S. |
  27. Holt, James M. |
  28. Hua, Kunjie |
  29. Jolley, Wesley J. |
  30. Lindholm, Anna K. |
  31. López-Fuster, María J. |
  32. Mitsainas, George |
  33. da Luz Mathias, Maria |
  34. McMillan, Leonard |
  35. Ramalhinho, Maria da Graça Morgado |
  36. Rehermann, Barbara |
  37. Rosshart, Stephan P. |
  38. Searle, Jeremy B. |
  39. Shiao, Meng-Shin |
  40. Solano, Emanuela |
  41. Svenson, Karen L. |
  42. Thomas-Laemont, Patricia |
  43. Threadgill, David W. |
  44. Ventura, Jacint |
  45. Weinstock, George M. |
  46. Pomp, Daniel |
  47. Churchill, Gary A. |
  48. Pardo-Manuel de Villena, Fernando |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-06-01
1000 Erschienen in
1000 Quellenangabe
  • 33(6): 1381-1395
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1093/molbev/msw036 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868115/ |
1000 Ergänzendes Material
  • https://academic.oup.com/mbe/article/33/6/1381/2579659#supplementary-data |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. Population-level sequencing data have enabled discoveries of selective sweeps associated with genes involved in recent adaptations in many species. In contrast, much debate but little evidence addresses whether “selfish” genes are capable of fixation—thereby leaving signatures identical to classical selective sweeps—despite being neutral or deleterious to organismal fitness. We previously described R2d2, a large copy-number variant that causes nonrandom segregation of mouse Chromosome 2 in females due to meiotic drive. Here we show population-genetic data consistent with a selfish sweep driven by alleles of R2d2 with high copy number (R2d2HC) in natural populations. We replicate this finding in multiple closed breeding populations from six outbred backgrounds segregating for R2d2 alleles. We find that R2d2HC rapidly increases in frequency, and in most cases becomes fixed in significantly fewer generations than can be explained by genetic drift. R2d2HC is also associated with significantly reduced litter sizes in heterozygous mothers, making it a true selfish allele. Our data provide direct evidence of populations actively undergoing selfish sweeps, and demonstrate that meiotic drive can rapidly alter the genomic landscape in favor of mutations with neutral or even negative effects on overall Darwinian fitness. Further study will reveal the incidence of selfish sweeps, and will elucidate the relative contributions of selfish genes, adaptation and genetic drift to evolution.
1000 Sacherschließung
lokal Meiotic Drive
lokal Selfish Genes
lokal Selective Sweep
lokal R2d2
lokal House Mouse
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Förderer
  1. National Institutes of Health
  2. National Science Foundation
  3. Vaadia-BARD
  4. U.S. Army Medical Research and Materiel Command
  5. The Jackson Laboratory
  6. National Center for Scientific Research, France
  7. University of Rome “La Sapienza”
  8. Claraz-Stiftung
  9. Natural Environment Research Council (UK)
  10. European Union
  11. Foundation for Science and Technology, Portugal
  12. Spanish “Ministerio de Ciencia y Tecnología”
  13. Spanish “Ministerio de Economía y Competitividad”
  14. School of Medicine at University of North Carolina
1000 Fördernummer
  1. T32GM067553; F30MH103925; P50GM076468; K01MH094406; DK-076050; DK-056350; AG038070
  2. IOS-1121273
  3. FI-478-13
  4. W81XWH-11-1-0762
  5. -
  6. ISEM 2016-002
  7. -
  8. -
  9. -
  10. CHRX-CT93-0192
  11. PTDC/BIA-EVF/116884/2010; UID/AMB/50017/2013
  12. CGL2007-62111
  13. CGL2010-15243
  14. -
1000 Förderprogramm
  1. intramural research program
  2. -
  3. Postdoctoral Fellowship
  4. -
  5. new investigator funds
  6. -
  7. -
  8. -
  9. -
  10. EU Human Capital and Mobility Programme
  11. -
  12. -
  13. -
  14. Oliver Smithies Investigator funds
1000 Dateien
  1. R2d2 Drives Selfish Sweeps in the House Mouse
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6407298.rdf
1000 Erstellt am 2018-03-26T13:12:37.622+0200
1000 Erstellt von 122
1000 beschreibt frl:6407298
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Mon Mar 26 13:15:40 CEST 2018
1000 Objekt bearb. Mon Mar 26 13:14:44 CEST 2018
1000 Vgl. frl:6407298
1000 Oai Id
  1. oai:frl.publisso.de:frl:6407298 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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