Download
8393-127458-7-PB.pdf 650,94KB
WeightNameValue
1000 Titel
  • Olfactory phenotypic expression unveils human aging
1000 Autor/in
  1. Mazzatenta, Andrea |
  2. Cellerino, Alessandro |
  3. Origlia, Nicola |
  4. Barloscio, Davide |
  5. Sartucci, Ferdinando |
  6. DI GIULIO, Camillo |
  7. Domenici, Luciano |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-03-26
1000 Erschienen in
1000 Quellenangabe
  • 7:19193-200
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.18632/oncotarget.8393 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27027240/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The mechanism of the natural aging of olfaction and its declinein the absence of any overt disease conditions remains unclear. Here, we investigated this mechanism through measurement of one of the parameters of olfactory function, the absolute threshold, in a healthy population from childhood to old age. The absolute olfactory threshold data were collected from an Italian observational study with 622 participants aged 5-105 years. A subjective testing procedure of constant stimuli was used, which was also compared to the ‘staircase’ method, with the calculation of the reliability. The n-butanol stimulus was used as an ascending series of nine molar concentrations that were monitored using an electronic nose. The data were analyzed using nonparametric statistics because of the multimodal distribution. We show that the age-related variations in the absolute olfactory threshold are not continuous; instead, there are multiple olfactory phenotypes. Three distinct age-related phenotypes were defined, termed as ‘juvenile’, ‘mature’ and ‘elder’. The frequency of these three phenotypes depends on age. Our data suggest that the sense of smell does not decrease linearly with aging. Our findings provide the basis for further understanding of olfactory loss as an anticipatory sign of aging and neurodegenerative processes.
1000 Sacherschließung
lokal absolute threshold
lokal olfactory phenotype
lokal olfaction
lokal olfactometry
lokal Gerotarget
lokal aging
1000 Fachgruppe
  1. Medizin |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/TWF6emF0ZW50YSwgQW5kcmVh|http://orcid.org/0000-0003-3834-0097|https://frl.publisso.de/adhoc/creator/T3JpZ2xpYSwgTmljb2xh|https://frl.publisso.de/adhoc/creator/QmFybG9zY2lvLCBEYXZpZGU=|https://frl.publisso.de/adhoc/creator/U2FydHVjY2ksIEZlcmRpbmFuZG8=|http://orcid.org/0000-0003-1073-6989|http://orcid.org/0000-0003-2923-9421
1000 Label
1000 Förderer
  1. Italian Ministry of Research
1000 Fördernummer
  1. PRIN 2010; IN-BDNF
1000 Förderprogramm
  1. -
1000 Dateien
  1. Olfactory phenotypic expression unveils human aging
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6407364.rdf
1000 Erstellt am 2018-03-29T11:26:15.831+0200
1000 Erstellt von 285
1000 beschreibt frl:6407364
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet 2020-01-30T18:55:44.329+0100
1000 Objekt bearb. Tue Apr 03 10:03:49 CEST 2018
1000 Vgl. frl:6407364
1000 Oai Id
  1. oai:frl.publisso.de:frl:6407364 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source