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Majek-et-al_2013_Sex differences in colorectal cancer survival.pdf 157,25KB
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1000 Titel
  • Sex Differences in Colorectal Cancer Survival: Population-Based Analysis of 164,996 Colorectal Cancer Patients in Germany
1000 Autor/in
  1. Majek, Ondrej |
  2. Gondos, Adam |
  3. Jansen, Lina |
  4. Emrich, Katharina |
  5. Holleczek, Bernd |
  6. Katalinic, Alexander |
  7. Nennecke, Alice |
  8. Eberle, Andrea |
  9. Brenner, Hermann |
1000 Mitwirkende/r
  1. The GEKID Cancer Survival Working Group |
1000 Erscheinungsjahr 2013
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2013-07-05
1000 Erschienen in
1000 Quellenangabe
  • 8(7):e68077
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2013
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1371/journal.pone.0068077 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702575/ |
1000 Ergänzendes Material
  • http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068077#s5 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Risk of colorectal cancer (CRC) is considerably higher in men compared to women; however, there is inconclusive evidence of sex differences in CRC prognosis. We aimed to assess and explain sex differences in 5-year relative survival using standard and model-based period analysis among 164,996 patients diagnosed with CRC from 1997 to 2006 and reported to 11 German cancer registries covering a population of 33 million inhabitants. Age-adjusted 5-year relative survival was higher in women (64.5% vs. 61.9%, P<0.0001). A substantial survival advantage of women was confirmed in multivariate analysis after adjusting for CRC stage and subsite in subjects under 65 years of age (relative excess risk, RER 0.86, 95% CI 0.82–0.90), but not in older subjects (RER 1.01, 95% CI 0.98–1.04); this pattern was similar in the 1st and in the 2nd to 5th year after diagnosis. The survival advantage of women varied by CRC stage and age and was most pronounced for localized disease (RERs 0.59–0.88 in various age subgroups) and in patients under 45 years of age (RERs 0.59, 0.72 and 0.76 in patients with localized, regional or advanced disease, respectively). On the contrary, sex differences in survival did not vary by location of CRC. In conclusion, our large population-based study confirmed a survival advantage of female compared to male CRC patients, most notably in young and middle aged patients and patients with localized disease. The effect of sex hormones, either endogenous or through hormonal replacement therapy, might be the most plausible explanation for the observed patterns.
1000 Sacherschließung
lokal Sex hormones
lokal Cancer detection and diagnosis
lokal Prognosis
lokal Colorectal cancer
lokal Rectum
lokal Colon
lokal Germany
lokal Age groups
1000 Fachgruppe
  1. Medizin |
  2. Gesundheitswesen |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/TWFqZWssIE9uZHJlag==|https://frl.publisso.de/adhoc/creator/R29uZG9zLCBBZGFt|https://frl.publisso.de/adhoc/creator/SmFuc2VuLCBMaW5h|https://frl.publisso.de/adhoc/creator/RW1yaWNoLCBLYXRoYXJpbmE=|https://frl.publisso.de/adhoc/creator/SG9sbGVjemVrLCBCZXJuZA==|https://frl.publisso.de/adhoc/creator/S2F0YWxpbmljLCBBbGV4YW5kZXI=|https://frl.publisso.de/adhoc/creator/TmVubmVja2UsIEFsaWNl|https://frl.publisso.de/adhoc/creator/RWJlcmxlLCBBbmRyZWE=|https://frl.publisso.de/adhoc/creator/QnJlbm5lciwgSGVybWFubg==|https://frl.publisso.de/adhoc/corporateBody/VGhlIEdFS0lEIENhbmNlciBTdXJ2aXZhbCBXb3JraW5nIEdyb3Vw
1000 Label
1000 Förderer
  1. German Cancer Aid (Deutsche Krebshilfe) |
  2. Masaryk University |
1000 Fördernummer
  1. 108257
  2. MUNI/A/0828/2011
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Cancer Aid (Deutsche Krebshilfe) |
    1000 Förderprogramm -
    1000 Fördernummer 108257
  2. 1000 joinedFunding-child
    1000 Förderer Masaryk University |
    1000 Förderprogramm -
    1000 Fördernummer MUNI/A/0828/2011
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6407388.rdf
1000 Erstellt am 2018-04-03T14:28:45.652+0200
1000 Erstellt von 266
1000 beschreibt frl:6407388
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Jan 30 18:54:49 CET 2020
1000 Objekt bearb. Fri Apr 06 16:01:59 CEST 2018
1000 Vgl. frl:6407388
1000 Oai Id
  1. oai:frl.publisso.de:frl:6407388 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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