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Nappo-et-al_2013_High-sensitivity c-reactive protein is a predictive factor of adiposity.pdf 733,50KB
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1000 Titel
  • High-sensitivity C-reactive Protein is a Predictive Factor of Adiposity in Children: Results of the Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and InfantS (IDEFICS) Study
1000 Autor/in
  1. Nappo, Annunziata |
  2. Iacoviello, Licia |
  3. Fraterman, Arno |
  4. González-Gil, Esther M. |
  5. Hadjigeorgiou, Charis |
  6. Marild, Staffan |
  7. Molnar, Dénes |
  8. Moreno, Luis A. |
  9. Peplies, Jenny |
  10. Sioen, Isabelle |
  11. Veidebaum, Toomas |
  12. Siani, Alfonso |
  13. Russo, Paola |
1000 Erscheinungsjahr 2013
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2013-06-06
1000 Erschienen in
1000 Quellenangabe
  • 2(3):e000101
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2013
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1161/JAHA.113.000101 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698769/ |
1000 Ergänzendes Material
  • http://jaha.ahajournals.org/content/2/3/e000101/tab-figures-data |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Whereas cross-sectional studies have shown that obesity is associated with increased C-reactive protein (CRP) levels in children, little is known about the impact of low-grade inflammation on body mass changes during growth. METHODS AND RESULTS: We assessed cross-sectionally and longitudinally the association of high-sensitivity (hs)-CRP levels with overweight/obesity and related cardiometabolic risk factors in the Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and InfantS (IDEFICS) cohort. 16 224 children from 8 European countries (2 to 9 years) were recruited during the baseline survey (T0). After the exclusion of 7187 children because of missing hs-CRP measurements and 2421 because of drug use during the previous week, the analysis was performed on 6616 children (Boys=3347; Girls=3269; age=6.3±1.7 years). Of them, 4110 were reexamined 2 years later (T1). Anthropometric variables, blood pressure, hs-CRP, blood lipids, glucose and insulin were measured. The population at T0 was divided into 3 categories, according to the baseline hs-CRP levels. Higher hs-CRP levels were associated with significantly higher prevalence of overweight/obesity, body mass index (BMI) z-score and central adiposity indices (P values all <0.0001), and with higher blood pressure and lower HDL-cholesterol levels. Over the 2-year follow-up, higher baseline hs-CRP levels were associated with a significant increase in BMI z-score (P<0.001) and significantly higher risk of incident overweight/obesity. CONCLUSIONS: Higher hs-CRP levels are associated to higher body mass and overweight/obesity risk in a large population of European children. Children with higher baseline levels of hs-CRP had a greater increase in BMI z-score and central adiposity over time and were at higher risk of developing overweight/obesity during growth.
1000 Sacherschließung
lokal C-reactive protein
lokal Pediatric obesity
lokal Population
lokal Inflammation
1000 Fachgruppe
  1. Medizin |
  2. Gesundheitswesen |
  3. Ernährungswissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/TmFwcG8sIEFubnVuemlhdGE=|https://frl.publisso.de/adhoc/creator/SWFjb3ZpZWxsbywgTGljaWE=|https://frl.publisso.de/adhoc/creator/IEZyYXRlcm1hbiwgQXJubw==|https://frl.publisso.de/adhoc/creator/R29uesOhbGV6LUdpbCwgRXN0aGVyIE0u|https://frl.publisso.de/adhoc/creator/SGFkamlnZW9yZ2lvdSwgQ2hhcmlz|https://frl.publisso.de/adhoc/creator/TWFyaWxkLCBTdGFmZmFu|https://frl.publisso.de/adhoc/creator/TW9sbmFyLCBEw6luZXM=|https://frl.publisso.de/adhoc/creator/TW9yZW5vLCBMdWlzIEEu|https://frl.publisso.de/adhoc/creator/UGVwbGllcywgSmVubnk=|https://frl.publisso.de/adhoc/creator/U2lvZW4sIElzYWJlbGxl|https://frl.publisso.de/adhoc/creator/VmVpZGViYXVtLCBUb29tYXM=|https://frl.publisso.de/adhoc/creator/U2lhbmksIEFsZm9uc28=|https://frl.publisso.de/adhoc/creator/UnVzc28sIFBhb2xh
1000 Förderer
  1. European Community |
  2. Research Foundation - Flanders |
1000 Fördernummer
  1. 016181 (FOOD)
  2. 1.2.683.11.N.00
1000 Förderprogramm
  1. Sixth Framework Programme
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Community |
    1000 Förderprogramm Sixth Framework Programme
    1000 Fördernummer 016181 (FOOD)
  2. 1000 joinedFunding-child
    1000 Förderer Research Foundation - Flanders |
    1000 Förderprogramm -
    1000 Fördernummer 1.2.683.11.N.00
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6407394.rdf
1000 Erstellt am 2018-04-03T15:08:35.967+0200
1000 Erstellt von 266
1000 beschreibt frl:6407394
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Fri Apr 06 15:53:58 CEST 2018
1000 Objekt bearb. Fri Apr 06 15:53:47 CEST 2018
1000 Vgl. frl:6407394
1000 Oai Id
  1. oai:frl.publisso.de:frl:6407394 |
1000 Sichtbarkeit Metadaten public
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