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A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice

  1. Ryan, DP
  2. Henzel, Kristin S.
  3. Pearson, BL
  4. Siwek, ME
  5. Papazoglou, Anna
  6. Guo, L.
  7. Paesler, K.
  8. Yu, M.
  9. Müller, R.
  10. Xie, R.
  11. Schröder, S.
  12. Becker, L.
  13. Garett, L.
  14. Hölter, SM
  15. Neff, F.
  16. Rácz, I.
  17. Rathkolb, B.
  18. Rozman, J.
  19. Ehninger, G.
  20. Klingenspor, M.
  21. Klopstock, T.
  22. Wolf, E.
  23. Wurst, W.
  24. Zimmer, A.
  25. Fuch, H.
  26. Gailus-Durner, V.
  27. Hrabě de Angelis, M.
  28. Sidiropoulou, K.
  29. Weiergräber, M.
  30. Zhou, Y.
  31. Ehninger, D.

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WeightNameValue
1000 Titel
  • A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice
1000 Autor/in
  1. Ryan, DP |
  2. Henzel, Kristin S. |
  3. Pearson, BL |
  4. Siwek, ME |
  5. Papazoglou, Anna |
  6. Guo, L. |
  7. Paesler, K. |
  8. Yu, M. |
  9. Müller, R. |
  10. Xie, R. |
  11. Schröder, S. |
  12. Becker, L. |
  13. Garett, L. |
  14. Hölter, SM |
  15. Neff, F. |
  16. Rácz, I. |
  17. Rathkolb, B. |
  18. Rozman, J. |
  19. Ehninger, G. |
  20. Klingenspor, M. |
  21. Klopstock, T. |
  22. Wolf, E. |
  23. Wurst, W. |
  24. Zimmer, A. |
  25. Fuch, H. |
  26. Gailus-Durner, V. |
  27. Hrabě de Angelis, M. |
  28. Sidiropoulou, K. |
  29. Weiergräber, M. |
  30. Zhou, Y. |
  31. Ehninger, D. |
1000 Erscheinungsjahr 2017
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-04-04
1000 Erschienen in
1000 Quellenangabe
  • 00: 1–11
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • http://doi.org/10.1038/mp.2017.53 |
1000 Ergänzendes Material
  • http://www.nature.com/articles/mp201753#supplementary-information |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Dietary intake of methyl donors, such as folic acid and methionine, shows considerable intra-individual variation in human populations. While it is recognized that maternal departures from the optimum of dietary methyl donor intake can increase the risk for mental health issues and neurological disorders in offspring, it has not been explored whether paternal dietary methyl donor intake influences behavioral and cognitive functions in the next generation. Here, we report that elevated paternal dietary methyl donor intake in a mouse model, transiently applied prior to mating, resulted in offspring animals (methyl donor-rich diet (MD) F1 mice) with deficits in hippocampus-dependent learning and memory, impaired hippocampal synaptic plasticity and reduced hippocampal theta oscillations. Gene expression analyses revealed altered expression of the methionine adenosyltransferase Mat2a and BK channel subunit Kcnmb2, which was associated with changes in Kcnmb2 promoter methylation in MD F1 mice. Hippocampal overexpression of Kcnmb2 in MD F1 mice ameliorated altered spatial learning and memory, supporting a role of this BK channel subunit in the MD F1 behavioral phenotype. Behavioral and gene expression changes did not extend into the F2 offspring generation. Together, our data indicate that paternal dietary factors influence cognitive and neural functions in the offspring generation.
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/UnlhbiwgRFA=|https://frl.publisso.de/adhoc/creator/SGVuemVsLCBLcmlzdGluIFMu|https://frl.publisso.de/adhoc/creator/UGVhcnNvbiwgQkw=|https://frl.publisso.de/adhoc/creator/U2l3ZWssIE1F|https://frl.publisso.de/adhoc/creator/UGFwYXpvZ2xvdSwgQW5uYQ==|https://frl.publisso.de/adhoc/creator/R3VvLCBMLg==|https://frl.publisso.de/adhoc/creator/UGFlc2xlciwgSy4=|https://frl.publisso.de/adhoc/creator/WXUsIE0u|https://frl.publisso.de/adhoc/creator/TcO8bGxlciwgUi4=|https://frl.publisso.de/adhoc/creator/WGllLCBSLg==|https://frl.publisso.de/adhoc/creator/U2NocsO2ZGVyLCBTLg==|https://frl.publisso.de/adhoc/creator/QmVja2VyLCBMLg==|https://frl.publisso.de/adhoc/creator/R2FyZXR0LCBMLg==|https://frl.publisso.de/adhoc/creator/SMO2bHRlciwgU00=|https://frl.publisso.de/adhoc/creator/TmVmZiwgRi4=|https://frl.publisso.de/adhoc/creator/UsOhY3osIEku|https://frl.publisso.de/adhoc/creator/UmF0aGtvbGIsIEIu|https://frl.publisso.de/adhoc/creator/Um96bWFuLCBKLg==|https://frl.publisso.de/adhoc/creator/RWhuaW5nZXIsIEcu|https://frl.publisso.de/adhoc/creator/S2xpbmdlbnNwb3IsIE0u|https://frl.publisso.de/adhoc/creator/S2xvcHN0b2NrLCBULg==|https://frl.publisso.de/adhoc/creator/V29sZiwgRS4=|https://frl.publisso.de/adhoc/creator/V3Vyc3QsIFcu|https://frl.publisso.de/adhoc/creator/WmltbWVyLCBBLg==|https://frl.publisso.de/adhoc/creator/RnVjaCwgSC4=|https://frl.publisso.de/adhoc/creator/R2FpbHVzLUR1cm5lciwgVi4=|https://frl.publisso.de/adhoc/creator/SHJhYsSbIGRlIEFuZ2VsaXMsIE0u|https://frl.publisso.de/adhoc/creator/U2lkaXJvcG91bG91LCBLLg==|https://frl.publisso.de/adhoc/creator/V2VpZXJncsOkYmVyLCBNLg==|https://frl.publisso.de/adhoc/creator/WmhvdSwgWS4=|https://frl.publisso.de/adhoc/creator/RWhuaW5nZXIsIEQu
1000 Label
1000 Förderer
  1. German Center for Neurodegenerative Diseases
  2. Federal Institute for Drugs and Medical Devices
  3. German Federal Ministry of Education and Research
  4. German Center for Diabetes Research
  5. German Center for Vertigo and Balance Disorders
  6. Helmholtz Alliance for Mental Health in Ageing Society
1000 Fördernummer
  1. -
  2. -
  3. 01KX1012
  4. -
  5. 01EO 0901
  6. HA-215
1000 Förderprogramm
  1. -
  2. -
  3. Infrafrontier
  4. -
  5. -
  6. -
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6407679.rdf
1000 Erstellt am 2018-04-17T09:09:45.403+0200
1000 Erstellt von 281
1000 beschreibt frl:6407679
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Thu Jan 30 18:53:08 CET 2020
1000 Objekt bearb. Wed Apr 18 10:02:23 CEST 2018
1000 Vgl. frl:6407679
1000 Oai Id
  1. oai:frl.publisso.de:frl:6407679 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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