Hypothalamic leptin action is mediated by histone deacetylase 5

  1. Kabra, Dhiraj G.
  2. Pfuhlmann, Katrin
  3. García-Cáceres, Cristina
  4. Schriever, Sonja C.
  5. Casquero García, Veronica
  6. Kebede, Adam Fiseha
  7. Fuente-Martin, Esther
  8. Trivedi, Chitrang
  9. Heppner, Kristy
  10. Uhlenhaut, N. Henriette
  11. Legutko, Beata
  12. Kabra, Uma D.
  13. Gao, Yuanqing
  14. Yi, Chun-Xia
  15. Quarta, Carmelo
  16. Clemmensen, Christoffer
  17. Finan, Brian
  18. Müller, Timo D.
  19. Meyer, Carola W.
  20. Paez-Pereda, Marcelo
  21. Stemmer, Kerstin
  22. Woods, Stephen C.
  23. Perez-Tilve, Diego
  24. Schneider, Robert
  25. Olson, Eric N.
  26. Tschöp, Matthias H.
  27. Pfluger, Paul ORCID logo

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WeightNameValue
1000 Titel
  • Hypothalamic leptin action is mediated by histone deacetylase 5
1000 Autor/in
  1. Kabra, Dhiraj G. |
  2. Pfuhlmann, Katrin |
  3. García-Cáceres, Cristina |
  4. Schriever, Sonja C. |
  5. Casquero García, Veronica |
  6. Kebede, Adam Fiseha |
  7. Fuente-Martin, Esther |
  8. Trivedi, Chitrang |
  9. Heppner, Kristy |
  10. Uhlenhaut, N. Henriette |
  11. Legutko, Beata |
  12. Kabra, Uma D. |
  13. Gao, Yuanqing |
  14. Yi, Chun-Xia |
  15. Quarta, Carmelo |
  16. Clemmensen, Christoffer |
  17. Finan, Brian |
  18. Müller, Timo D. |
  19. Meyer, Carola W. |
  20. Paez-Pereda, Marcelo |
  21. Stemmer, Kerstin |
  22. Woods, Stephen C. |
  23. Perez-Tilve, Diego |
  24. Schneider, Robert |
  25. Olson, Eric N. |
  26. Tschöp, Matthias H. |
  27. Pfluger, Paul |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-02-29
1000 Erschienen in
1000 Quellenangabe
  • 7(1):10782
1000 FRL-Sammlung
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1038/ncomms10782 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773494/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/ncomms10782#supplementary-information |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Hypothalamic leptin signalling has a key role in food intake and energy-balance control and is often impaired in obese individuals. Here we identify histone deacetylase 5 (HDAC5) as a regulator of leptin signalling and organismal energy balance. Global HDAC5 KO mice have increased food intake and greater diet-induced obesity when fed high-fat diet. Pharmacological and genetic inhibition of HDAC5 activity in the mediobasal hypothalamus increases food intake and modulates pathways implicated in leptin signalling. We show HDAC5 directly regulates STAT3 localization and transcriptional activity via reciprocal STAT3 deacetylation at Lys685 and phosphorylation at Tyr705. In vivo, leptin sensitivity is substantially impaired in HDAC5 loss-of-function mice. Hypothalamic HDAC5 overexpression improves leptin action and partially protects against HFD-induced leptin resistance and obesity. Overall, our data suggest that hypothalamic HDAC5 activity is a regulator of leptin signalling that adapts food intake and body weight to our dietary environment.
1000 Sacherschließung
lokal Cell signalling
lokal Medical research
lokal Hypothalamus
lokal Metabolism
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/S2FicmEsIERoaXJhaiBHLiA=|https://frl.publisso.de/adhoc/creator/UGZ1aGxtYW5uLCBLYXRyaW4g|https://frl.publisso.de/adhoc/creator/R2FyY8OtYS1Dw6FjZXJlcywgQ3Jpc3RpbmEg|https://frl.publisso.de/adhoc/creator/U2NocmlldmVyLCBTb25qYSBDLiA=|https://frl.publisso.de/adhoc/creator/Q2FzcXVlcm8gR2FyY8OtYSwgVmVyb25pY2Eg|https://frl.publisso.de/adhoc/creator/S2ViZWRlLCBBZGFtIEZpc2VoYSA=|https://frl.publisso.de/adhoc/creator/RnVlbnRlLU1hcnRpbiwgRXN0aGVyIA==|https://frl.publisso.de/adhoc/creator/VHJpdmVkaSwgQ2hpdHJhbmcg|https://frl.publisso.de/adhoc/creator/SGVwcG5lciwgS3Jpc3R5IA==|https://frl.publisso.de/adhoc/creator/VWhsZW5oYXV0LCBOLiBIZW5yaWV0dGUg|https://frl.publisso.de/adhoc/creator/TGVndXRrbywgQmVhdGEg|https://frl.publisso.de/adhoc/creator/S2FicmEsIFVtYSBELiA=|https://frl.publisso.de/adhoc/creator/R2FvLCBZdWFucWluZyA=|https://frl.publisso.de/adhoc/creator/WWksIENodW4tWGlhIA==|https://frl.publisso.de/adhoc/creator/UXVhcnRhLCBDYXJtZWxvIA==|https://frl.publisso.de/adhoc/creator/Q2xlbW1lbnNlbiwgQ2hyaXN0b2ZmZXIg|https://frl.publisso.de/adhoc/creator/RmluYW4sIEJyaWFuIA==|https://frl.publisso.de/adhoc/creator/TcO8bGxlciwgVGltbyBELiA=|https://frl.publisso.de/adhoc/creator/TWV5ZXIsIENhcm9sYSBXLiA=|https://frl.publisso.de/adhoc/creator/UGFlei1QZXJlZGEsIE1hcmNlbG8g|https://frl.publisso.de/adhoc/creator/U3RlbW1lciwgS2Vyc3RpbiA=|https://frl.publisso.de/adhoc/creator/V29vZHMsIFN0ZXBoZW4gQy4g|https://frl.publisso.de/adhoc/creator/UGVyZXotVGlsdmUsIERpZWdvIA==|https://frl.publisso.de/adhoc/creator/U2NobmVpZGVyLCBSb2JlcnQg|https://frl.publisso.de/adhoc/creator/T2xzb24sIEVyaWMgTi4g|https://frl.publisso.de/adhoc/creator/VHNjaMO2cCwgTWF0dGhpYXMgSC4g|http://orcid.org/0000-0002-8118-7588
1000 Förderer
  1. Helmholtz Alliance ICEMED—Imaging and Curing Environmental Metabolic Diseases
  2. Center for Diabetes Research (DZD)
  3. European Commission
  4. Helmholtz Association
1000 Fördernummer
  1. -
  2. -
  3. 241592
  4. -
1000 Förderprogramm
  1. -
  2. -
  3. FP7- HEALTH- 2009- 241592 EurOCHIP grant
  4. Helmholtz Portfolio Theme ‘Metabolic Dysfunction and Common Disease’
1000 Dateien
  1. Hypothalamic leptin action is mediated by histone deacetylase 5
    Hypothalamic leptin action is mediated by histone deacetylase 5
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6407724.rdf
1000 Erstellt am 2018-04-18T10:31:46.402+0200
1000 Erstellt von 218
1000 beschreibt frl:6407724
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Tue May 08 10:06:22 CEST 2018
1000 Objekt bearb. Tue May 08 10:06:05 CEST 2018
1000 Vgl. frl:6407724
1000 Oai Id
  1. oai:frl.publisso.de:frl:6407724 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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