Single cell polarity in liquid phase facilitates tumour metastasis

  1. Lorentzen, Anna ORCID logo
  2. Becker, Paul F.
  3. Kosla, Jan
  4. Saini,Massimo
  5. Weidele, Kathrin
  6. Ronchi, Paolo
  7. Klein, Corinna
  8. Wolf, Monika J.
  9. Geist, Felix
  10. Seubert, Bastian
  11. Ringelhan, Marc ORCID logo
  12. Mihic-Probst, Daniela
  13. Esser, Knud
  14. Roblek, Marko
  15. Kuehne, Felix
  16. Bianco, Gaia
  17. O’Connor, Tracy
  18. Müller, Quentin
  19. Schuck, Kathleen
  20. Lange, Sebastian ORCID logo
  21. Hartmann, Daniel ORCID logo
  22. Spaich, Saskia
  23. Groß, Olaf
  24. Utikal, Jochen
  25. Haferkamp, Sebastian
  26. Sprick, Martin R.
  27. Damle-Vartak, Dr. Amruta ORCID logo
  28. Hapfelmeier, Alexander
  29. Hüser, Norbert
  30. Protzer, Ulrike ORCID logo
  31. Trumpp, Andreas
  32. Saur, Dieter
  33. Vartak, Nachiket ORCID logo
  34. Klein, Christoph A. ORCID logo
  35. Polzer, Bernhard ORCID logo
  36. Borsig, Lubor ORCID logo
  37. Heikenwalder, Mathias

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WeightNameValue
1000 Titel
  • Single cell polarity in liquid phase facilitates tumour metastasis
1000 Autor/in
  1. Lorentzen, Anna |
  2. Becker, Paul F. |
  3. Kosla, Jan |
  4. Saini,Massimo |
  5. Weidele, Kathrin |
  6. Ronchi, Paolo |
  7. Klein, Corinna |
  8. Wolf, Monika J. |
  9. Geist, Felix |
  10. Seubert, Bastian |
  11. Ringelhan, Marc |
  12. Mihic-Probst, Daniela |
  13. Esser, Knud |
  14. Roblek, Marko |
  15. Kuehne, Felix |
  16. Bianco, Gaia |
  17. O’Connor, Tracy |
  18. Müller, Quentin |
  19. Schuck, Kathleen |
  20. Lange, Sebastian |
  21. Hartmann, Daniel |
  22. Spaich, Saskia |
  23. Groß, Olaf |
  24. Utikal, Jochen |
  25. Haferkamp, Sebastian |
  26. Sprick, Martin R. |
  27. Damle-Vartak, Dr. Amruta |
  28. Hapfelmeier, Alexander |
  29. Hüser, Norbert |
  30. Protzer, Ulrike |
  31. Trumpp, Andreas |
  32. Saur, Dieter |
  33. Vartak, Nachiket |
  34. Klein, Christoph A. |
  35. Polzer, Bernhard |
  36. Borsig, Lubor |
  37. Heikenwalder, Mathias |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-02-28
1000 Erschienen in
1000 Quellenangabe
  • 9:887
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.1038/s41467-018-03139-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830403/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41467-018-03139-6#Sec49 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Dynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established, polarisation of metastasising tumour cells during phases of detachment has not been investigated. Here we identify and characterise a type of polarisation maintained by single cells in liquid phase termed single-cell (sc) polarity and investigate its role during metastasis. We demonstrate that sc polarity is an inherent feature of cells from different tumour entities that is observed in circulating tumour cells in patients. Functionally, we propose that the sc pole is directly involved in early attachment, thereby affecting adhesion, transmigration and metastasis. In vivo, the metastatic capacity of cell lines correlates with the extent of sc polarisation. By manipulating sc polarity regulators and by generic depolarisation, we show that sc polarity prior to migration affects transmigration and metastasis in vitro and in vivo.
1000 Sacherschließung
lokal cancer
lokal actin
lokal cell polarity
lokal cell adhesion
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0002-4405-935X|https://frl.publisso.de/adhoc/creator/QmVja2VyLCBQYXVsIEYu|https://frl.publisso.de/adhoc/creator/S29zbGEsIEphbg==|https://frl.publisso.de/adhoc/creator/U2FpbmksTWFzc2ltbw==|https://frl.publisso.de/adhoc/creator/V2VpZGVsZSwgS2F0aHJpbg==|https://frl.publisso.de/adhoc/creator/Um9uY2hpLCBQYW9sbw==|https://frl.publisso.de/adhoc/creator/S2xlaW4sIENvcmlubmE=|https://frl.publisso.de/adhoc/creator/V29sZiwgTW9uaWthIEou|https://frl.publisso.de/adhoc/creator/R2Vpc3QsIEZlbGl4|https://frl.publisso.de/adhoc/creator/U2V1YmVydCwgQmFzdGlhbg==|http://orcid.org/0000-0003-3131-5657|https://frl.publisso.de/adhoc/creator/TWloaWMtUHJvYnN0LCBEYW5pZWxh|https://frl.publisso.de/adhoc/creator/RXNzZXIsIEtudWQ=|https://frl.publisso.de/adhoc/creator/Um9ibGVrLCBNYXJrbw==|https://frl.publisso.de/adhoc/creator/S3VlaG5lLCBGZWxpeA==|https://frl.publisso.de/adhoc/creator/IEJpYW5jbywgR2FpYQ==|https://frl.publisso.de/adhoc/creator/T_KAmUNvbm5vciwgVHJhY3k=|https://frl.publisso.de/adhoc/creator/TcO8bGxlciwgUXVlbnRpbg==|https://frl.publisso.de/adhoc/creator/U2NodWNrLCBLYXRobGVlbg==|http://orcid.org/0000-0003-0406-1401|https://orcid.org/0000-0003-4366-8986|https://frl.publisso.de/adhoc/creator/U3BhaWNoLCBTYXNraWE=|https://frl.publisso.de/adhoc/creator/R3Jvw58sIE9sYWY=|https://frl.publisso.de/adhoc/creator/VXRpa2FsLCBKb2NoZW4=|https://frl.publisso.de/adhoc/creator/SGFmZXJrYW1wLCBTZWJhc3RpYW4=|https://frl.publisso.de/adhoc/creator/U3ByaWNrLCBNYXJ0aW4gUi4=|https://orcid.org/0000-0001-6091-4937|https://frl.publisso.de/adhoc/creator/SGFwZmVsbWVpZXIsIEFsZXhhbmRlcg==|https://frl.publisso.de/adhoc/creator/IEjDvHNlciwgTm9yYmVydA==|http://orcid.org/0000-0002-9421-1911|https://frl.publisso.de/adhoc/creator/VHJ1bXBwLCBBbmRyZWFz|https://frl.publisso.de/adhoc/creator/U2F1ciwgRGlldGVy|http://orcid.org/0000-0002-2966-4631|http://orcid.org/0000-0001-7128-1725|http://orcid.org/0000-0002-3797-9975|http://orcid.org/0000-0003-2263-9545|https://frl.publisso.de/adhoc/creator/SGVpa2Vud2FsZGVyLCBNYXRoaWFz
1000 Label
1000 Förderer
  1. Horizon 2020 Framework Programme |
1000 Fördernummer
  1. 667273
1000 Förderprogramm
  1. -
1000 Dateien
  1. Single cell polarity in liquid phase facilitates tumour metastasis
    Single cell polarity in liquid phase facilitates tumour metastasis
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Horizon 2020 Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer 667273
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6408022.rdf
1000 Erstellt am 2018-05-14T09:31:15.359+0200
1000 Erstellt von 254
1000 beschreibt frl:6408022
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Wed Apr 21 12:53:34 CEST 2021
1000 Objekt bearb. Wed Apr 21 12:53:34 CEST 2021
1000 Vgl. frl:6408022
1000 Oai Id
  1. oai:frl.publisso.de:frl:6408022 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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