Psychosocial Stress and Immunity—What Can We Learn From Pig Studies_.pdf 258,19KB
1000 Titel
  • Psychosocial Stress and Immunity—What Can We Learn From Pig Studies?
1000 Autor/in
  1. Gimsa, Ulrike |
  2. Tuchscherer, Margret |
  3. Kanitz, Ellen |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-04-03
1000 Erschienen in
1000 Quellenangabe
  • 12:64
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • |
  • |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Psychosocial stress may impair immune functions and provoke the development of pathologies. The underlying communication between the brain and the immune system is being studied predominantly in rodents. However, pigs offer several advantages as preclinical models for humans because pigs are more similar to humans than rodents in many anatomical and physiological characteristics. Unlike in rodents, the main stress-induced glucocorticoid in humans and pigs is cortisol with a similar circadian rhythm. In this study, we summarize data on short-term and long-term effects of social stress in pigs for their immunity and neuroendocrine regulation with consequences for their health and well-being. As typical social stressors, regrouping, crowding, social isolation, and maternal deprivation have been studied. Psychosocial stress in pigs may affect various reactions of innate and adaptive immunity, such as leukocyte distribution, cytokine secretion, lymphocyte proliferation, and antibody production as well as immune responses to viral infection or vaccination. Furthermore, social stress may induce or promote gastrointestinal diseases through dysregulation of inflammatory processes. In piglets, psychosocial stress may also result in glucocorticoid resistance of lymphocytes, which has been discussed as a cause of allergic asthma in humans. Stress-related neuroendocrine alterations in the cortico-limbic structures, such as the prefrontal cortex, amygdala, hippocampus and hypothalamus, have been demonstrated in pigs at different ages. Based on these data, we propose using pigs as models for psychosocial stress in humans to study the mechanisms of brain-to-immune and immune-to-brain communication from the systemic level down to the cellular and subcellular levels.
1000 Sacherschließung
lokal neuroendocrine regulation
lokal inflammation
lokal immunity
lokal social stress
lokal Sus scrofa
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
1000 (Academic) Editor
1000 Label
1000 Förderer
  1. Leibniz Association |
  2. Leibniz Institute for Farm Animal Biology (FBN) |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. Open Access Fund
  2. Open Access Fund
1000 Dateien
  1. Psychosocial Stress and Immunity—What Can We Learn From Pig Studies?
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Leibniz Association |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Leibniz Institute for Farm Animal Biology (FBN) |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6408988.rdf
1000 Erstellt am 2018-07-20T12:39:21.322+0200
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1000 Zuletzt bearbeitet Thu Jan 30 21:42:35 CET 2020
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