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1000 Titel
  • Transcriptomic data from panarthropods shed new light on the evolution of insulator binding proteins in insects
1000 Autor/in
  1. Pauli, Thomas |
  2. Vedder, Lucia |
  3. Dowling, Daniel |
  4. Petersen, Malte |
  5. Meusemann, Karen |
  6. Donath, Alexander |
  7. Peters, Ralph S. |
  8. Podsiadlowski, Lars |
  9. Mayer, Christoph |
  10. Liu, Shanlin |
  11. Zhou, Xin |
  12. Heger, Peter |
  13. Wiehe, Thomas |
  14. Hering, Lars |
  15. Mayer, Georg |
  16. Misof, Bernhard |
  17. Niehuis, Oliver |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-11-03
1000 Erschienen in
1000 Quellenangabe
  • 17:861
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12864-016-3205-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094011/ |
1000 Ergänzendes Material
  • https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-3205-1#Declarations |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Body plan development in multi-cellular organisms is largely determined by homeotic genes. Expression of homeotic genes, in turn, is partially regulated by insulator binding proteins (IBPs). While only a few enhancer blocking IBPs have been identified in vertebrates, the common fruit fly Drosophila melanogaster harbors at least twelve different enhancer blocking IBPs. We screened recently compiled insect transcriptomes from the 1KITE project and genomic and transcriptomic data from public databases, aiming to trace the origin of IBPs in insects and other arthropods. RESULTS: Our study shows that the last common ancestor of insects (Hexapoda) already possessed a substantial number of IBPs. Specifically, of the known twelve insect IBPs, at least three (i.e., CP190, Su(Hw), and CTCF) already existed prior to the evolution of insects. Furthermore we found GAF orthologs in early branching insect orders, including Zygentoma (silverfish and firebrats) and Diplura (two-pronged bristletails). Mod(mdg4) is most likely a derived feature of Neoptera, while Pita is likely an evolutionary novelty of holometabolous insects. Zw5 appears to be restricted to schizophoran flies, whereas BEAF-32, ZIPIC and the Elba complex, are probably unique to the genus Drosophila. Selection models indicate that insect IBPs evolved under neutral or purifying selection. CONCLUSIONS: Our results suggest that a substantial number of IBPs either pre-date the evolution of insects or evolved early during insect evolution. This suggests an evolutionary history of insulator binding proteins in insects different to that previously thought. Moreover, our study demonstrates the versatility of the 1KITE transcriptomic data for comparative analyses in insects and other arthropods.
1000 Sacherschließung
lokal Gene evolution
lokal Insulator binding proteins
lokal Comparative transcriptomic analyses
lokal Arthropod evolution
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/UGF1bGksIFRob21hcw==|https://frl.publisso.de/adhoc/creator/VmVkZGVyLCBMdWNpYQ==|https://frl.publisso.de/adhoc/creator/RG93bGluZywgRGFuaWVs|http://orcid.org/0000-0001-7601-9873|https://frl.publisso.de/adhoc/creator/TWV1c2VtYW5uLCBLYXJlbg==|http://orcid.org/0000-0001-5618-0547|https://frl.publisso.de/adhoc/creator/UGV0ZXJzLCBSYWxwaCBTLg==|https://frl.publisso.de/adhoc/creator/UG9kc2lhZGxvd3NraSwgTGFycw==|http://orcid.org/0000-0001-5104-6621|https://frl.publisso.de/adhoc/creator/TGl1LCBTaGFubGlu|https://frl.publisso.de/adhoc/creator/WmhvdSwgWGlu|https://frl.publisso.de/adhoc/creator/SGVnZXIsIFBldGVy|https://frl.publisso.de/adhoc/creator/V2llaGUsIFRob21hcw==|https://frl.publisso.de/adhoc/creator/SGVyaW5nLCBMYXJz|https://frl.publisso.de/adhoc/creator/TWF5ZXIsIEdlb3Jn|https://frl.publisso.de/adhoc/creator/TWlzb2YsIEJlcm5oYXJk|https://frl.publisso.de/adhoc/creator/TmllaHVpcywgT2xpdmVy
1000 Label
1000 Förderer
  1. BGI
  2. German Research Foundation
1000 Fördernummer
  1. -
  2. SFB 680
1000 Förderprogramm
  1. -
  2. Molecular Basis of Evolutionary Innovations
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6409040.rdf
1000 Erstellt am 2018-07-26T09:54:40.580+0200
1000 Erstellt von 122
1000 beschreibt frl:6409040
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet 2020-01-30T16:45:44.601+0100
1000 Objekt bearb. Thu Jul 26 10:02:12 CEST 2018
1000 Vgl. frl:6409040
1000 Oai Id
  1. oai:frl.publisso.de:frl:6409040 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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