Air Pollution and Atherosclerosis: A Cross-Sectional Analysis of Four European Cohort Studies in the ESCAPE Study

  1. Perez, Laura
  2. Wolf, Kathrin
  3. Hennig, Frauke
  4. Penell, Johanna
  5. Basagaña, Xavier
  6. Foraster, Maria
  7. Aguilera, Inmaculada
  8. Agis, David
  9. Beelen, Rob
  10. Brunekreef, Bert
  11. Cyrys, Josef
  12. Fuks, Kateryna B.
  13. Adam, Martin
  14. Baldassarre, Damiano
  15. Cirach, Marta
  16. Elosua, Roberto
  17. Dratva, Julia
  18. Hampel, Regina
  19. Koenig, Wolfgang
  20. Marrugat, Jaume
  21. de Faire, Ulf
  22. Pershagen, Göran
  23. Probst-Hensch, Nicole M.
  24. de Nazelle, Audrey
  25. Nieuwenhuijsen, Mark J.
  26. Rathmann, Wolfgang
  27. Rivera, Marcela
  28. Seissler, Jochen
  29. Schindler, Christian
  30. Thiery, Joachim
  31. Hoffmann, Barbara
  32. Peters, Annette
  33. Künzli, Nino

WeightNameValue
1000 Titel
  • Air Pollution and Atherosclerosis: A Cross-Sectional Analysis of Four European Cohort Studies in the ESCAPE Study
1000 Autor/in
  1. Perez, Laura |
  2. Wolf, Kathrin |
  3. Hennig, Frauke |
  4. Penell, Johanna |
  5. Basagaña, Xavier |
  6. Foraster, Maria |
  7. Aguilera, Inmaculada |
  8. Agis, David |
  9. Beelen, Rob |
  10. Brunekreef, Bert |
  11. Cyrys, Josef |
  12. Fuks, Kateryna B. |
  13. Adam, Martin |
  14. Baldassarre, Damiano |
  15. Cirach, Marta |
  16. Elosua, Roberto |
  17. Dratva, Julia |
  18. Hampel, Regina |
  19. Koenig, Wolfgang |
  20. Marrugat, Jaume |
  21. de Faire, Ulf |
  22. Pershagen, Göran |
  23. Probst-Hensch, Nicole M. |
  24. de Nazelle, Audrey |
  25. Nieuwenhuijsen, Mark J. |
  26. Rathmann, Wolfgang |
  27. Rivera, Marcela |
  28. Seissler, Jochen |
  29. Schindler, Christian |
  30. Thiery, Joachim |
  31. Hoffmann, Barbara |
  32. Peters, Annette |
  33. Künzli, Nino |
1000 Erscheinungsjahr 2015
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-01-27
1000 Erschienen in
1000 Quellenangabe
  • 123(6):597-605
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455580/ |
  • http://dx.doi.org/10.1289/ehp.1307711 |
1000 Ergänzendes Material
  • https://ehp.niehs.nih.gov/1307711/#tab3 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: In four European cohorts, we investigated the cross-sectional association between long-term exposure to air pollution and intima-media thickness of the common carotid artery (CIMT), a preclinical marker of atherosclerosis. METHODS: Individually assigned levels of nitrogen dioxide, nitrogen oxides, particulate matter ≤ 2.5 μm (PM2.5), absorbance of PM2.5 (PM2.5abs), PM10, PMcoarse, and two indicators of residential proximity to highly trafficked roads were obtained under a standard exposure protocol (European Study of Cohorts for Air Pollution Effects—ESCAPE study) in the Stockholm area (Sweden), the Ausburg and Ruhr area (Germany), and the Girona area (Spain). We used linear regression and meta-analyses to examine the association between long-term exposure to air pollution and CIMT. RESULTS: The meta-analysis with 9,183 individuals resulted in an estimated increase in CIMT (geometric mean) of 0.72% (95% CI: –0.65%, 2.10%) per 5-μg/m3 increase in PM2.5 and 0.42% (95% CI: –0.46%, 1.30%) per 10–5/m increase in PM2.5abs. Living in proximity to high traffic was also positively but not significantly associated with CIMT. Meta-analytic estimates for other pollutants were inconsistent. Results were similar across different adjustment sets and sensitivity analyses. In an extended meta-analysis for PM2.5 with three other previously published studies, a 0.78% (95% CI: –0.18%, 1.75%) increase in CIMT was estimated for a 5-μg/m3 contrast in PM2.5. CONCLUSIONS: Using a standardized exposure and analytical protocol in four European cohorts, we found that cross-sectional associations between CIMT and the eight ESCAPE markers of long-term residential air pollution exposure did not reach statistical significance. The additional meta-analysis of CIMT and PM2.5 across all published studies also was positive but not significant.
1000 Fachgruppe
  1. Medizin |
  2. Umweltwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Erstellt am 2018-08-09T13:24:50.967+0200
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1000 Zuletzt bearbeitet Thu Aug 09 13:25:17 CEST 2018
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