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WeightNameValue
1000 Titel
  • Clay-induced DNA breaks as a path for genetic diversity, antibiotic resistance, and asbestos carcinogenesis
1000 Autor/in
  1. Gonzalez Tortuero, Enrique |
  2. Rodríguez-Beltrán, Jerónimo |
  3. Radek, Renate |
  4. Blázquez, Jesús |
  5. Rodríguez-Rojas, Alexandro |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-05-31
1000 Erschienen in
1000 Quellenangabe
  • 8:8504
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41598-018-26958-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981458/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41598-018-26958-5#Sec21 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Natural clays and synthetic nanofibres can have a severe impact on human health. After several decades of research, the molecular mechanism of how asbestos induces cancer is not well understood. Different fibres, including asbestos, can penetrate cell membranes and introduce foreign DNA in bacterial and eukaryotic cells. Incubating Escherichia coli under friction forces with sepiolite, a clayey material, or with asbestos, causes double-strand DNA breaks. Antibiotics and clays are used together in animal husbandry, the mutagenic effect of these fibres could be a pathway to antibiotic resistance due to the friction provided by peristalsis of the gut from farm animals in addition to horizontal gene transfer. Moreover, we raise the possibility that the same mechanism could generate bacteria diversity in natural scenarios, playing a role in the evolution of species. Finally, we provide a new model on how asbestos may promote mutagenesis and cancer based on the observed mechanical genotoxicity.
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0001-8934-6822|http://orcid.org/0000-0003-3014-1229|https://frl.publisso.de/adhoc/creator/UmFkZWssIFJlbmF0ZQ==|https://frl.publisso.de/adhoc/creator/QmzDoXpxdWV6LCBKZXPDunM=|http://orcid.org/0000-0002-4119-8127
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. Spanish Network for Research in Infectious Diseases (Ministerio de Economía y Competitividad) |
1000 Fördernummer
  1. SFB 973
  2. REIPI RD12/0015
1000 Förderprogramm
  1. Project C5
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm Project C5
    1000 Fördernummer SFB 973
  2. 1000 joinedFunding-child
    1000 Förderer Spanish Network for Research in Infectious Diseases (Ministerio de Economía y Competitividad) |
    1000 Förderprogramm -
    1000 Fördernummer REIPI RD12/0015
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6409479.rdf
1000 Erstellt am 2018-08-21T12:29:10.804+0200
1000 Erstellt von 294
1000 beschreibt frl:6409479
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Jan 30 21:46:14 CET 2020
1000 Objekt bearb. Fri Aug 24 12:37:41 CEST 2018
1000 Vgl. frl:6409479
1000 Oai Id
  1. oai:frl.publisso.de:frl:6409479 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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