1-s2.0-S1521690X17301008-main.pdf 308,09KB
1000 Titel
  • Functional analysis of the IGF-system in milk
1000 Autor/in
  1. Hoeflich, Andreas |
  2. Meyer, Zianka |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-10-20
1000 Erschienen in
1000 Quellenangabe
  • 31(4):409-418
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The development of milk during evolution is considered a more recent step to provide the neonate with adequate amounts of energy, nutrients, and specific hormonal signals thereby, granting a fast and efficient rate of postnatal growth and development. Since the insulin- or the insulin-like growth factor (IGF) systems were evolved much earlier, it can be assumed that the functionality of the IGF-system has been integrated into the novel matrix milk containing casein and whey proteins from the beginnings. In fact, IGFs and IGF-binding proteins (IGFBPs) are abundantly present in milk, which is particularly true for fore-milk or colostrum and the potential effects of milk-borne IGF-compounds on the consuming organisms have in fact been addressed by several studies. Those studies examined, if orally administered IGFs can be absorbed by the consumer's gastro-intestinal tract and thus contribute e.g. to the somatic growth of infants. A second line of studies assessed local effects of milk-borne IGFs on growth and development of the gastro-intestinal tract itself. Finally, distinct functions of isolated IGF-compounds for growth and involution of the mammary gland have also been provided in the past. While the consumption of milk seems not to represent a major source of endogenous IGFs, accumulating evidence indicates secondary effects of milk on the endogenous IGF-system, which may be mediated by micronutrients such as branched amino acids and metabolic programming. By contrast, direct effects on growth and development of oesophageal and intestinal cells have been observed if IGFs were administered orally.
1000 Sacherschließung
lokal IGFBP
lokal local and systemic effects
lokal milk
lokal IGF
lokal casein
lokal micronutrients
1000 Fachgruppe
  1. Biologie |
  2. Ernährungswissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
1000 Label
1000 Förderer
  1. Leibniz Institute for Farm Animal Biology (FBN) |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. Open Access Fund
1000 Dateien
  1. Functional analysis of the IGF-system in milk
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Leibniz Institute for Farm Animal Biology (FBN) |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410279.rdf
1000 Erstellt am 2018-09-20T10:40:58.768+0200
1000 Erstellt von 25
1000 beschreibt frl:6410279
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Jan 30 21:52:19 CET 2020
1000 Objekt bearb. Thu Sep 20 10:41:35 CEST 2018
1000 Vgl. frl:6410279
1000 Oai Id
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