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Schink-et-al_2018_Risk of ischemic stroke and the use of individual non-steroidal anti-inflammatory drugs_A multi-country European database study within the SOS Project.pdf 2,05MB
WeightNameValue
1000 Titel
  • Risk of ischemic stroke and the use of individual non-steroidal anti-inflammatory drugs: A multi-country European database study within the SOS Project
1000 Autor/in
  1. Schink, Tania |
  2. Kollhorst, Bianca |
  3. Varas Lorenzo, Cristina |
  4. Arfè, Andrea |
  5. Herings, Ron |
  6. Lucchi, Silvia |
  7. Romio, Silvana |
  8. Schade, René |
  9. Schuemie, Martijn J. |
  10. Straatman, Huub |
  11. Valkhoff, Vera |
  12. Villa, Marco |
  13. Sturkenboom, Miriam |
  14. Garbe, Edeltraut |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-09-19
1000 Erschienen in
1000 Quellenangabe
  • 13(9):e0203362
1000 Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1371/journal.pone.0203362 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145581/ |
1000 Ergänzendes Material
  • https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203362#sec009 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND AND PURPOSE: A multi-country European study using data from six healthcare databases from four countries was performed to evaluate in a large study population (>32 million) the risk of ischemic stroke (IS) associated with individual NSAIDs and to assess the impact of risk factors of IS and co-medication. METHODS: Case-control study nested in a cohort of new NSAID users. For each case, up to 100 sex- and age-matched controls were selected and confounder-adjusted odds ratios for current use of individual NSAIDs compared to past use calculated. RESULTS: 49,170 cases of IS were observed among 4,593,778 new NSAID users. Use of coxibs (odds ratio 1.08, 95%-confidence interval 1.02–1.15) and use of traditional NSAIDs (1.16, 1.12–1.19) were associated with an increased risk of IS. Among 32 individual NSAIDs evaluated, the highest significant risk of IS was observed for ketorolac (1.46, 1.19–1.78), but significantly increased risks (in decreasing order) were also found for diclofenac, indomethacin, rofecoxib, ibuprofen, nimesulide, diclofenac with misoprostol, and piroxicam. IS risk associated with NSAID use was generally higher in persons of younger age, males, and those with a prior history of IS. CONCLUSIONS: Risk of IS differs between individual NSAIDs and appears to be higher in patients with a prior history of IS or transient ischemic attack (TIA), in younger or male patients. Co-medication with aspirin, other antiplatelets or anticoagulants might mitigate this risk. The small to moderate observed risk increase (by 13–46%) associated with NSAIDs use represents a public health concern due to widespread NSAID usage.
1000 Freie Schlagwörter
  • Drug information
  • NSAIDs
  • Drug research and development
  • Antihypertensive drugs
  • Ischemic stroke
  • Platelet aggregation
  • Anticoagulants
  • Rheumatoid arthritis
1000 Fachgruppe
  1. Medizin |
  2. Gesundheitswesen |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0002-0224-1866|https://frl.publisso.de/adhoc/creator/S29sbGhvcnN0LCBCaWFuY2E=|https://frl.publisso.de/adhoc/creator/VmFyYXMgTG9yZW56bywgQ3Jpc3RpbmE=|https://frl.publisso.de/adhoc/creator/QXJmw6gsIEFuZHJlYQ==|https://frl.publisso.de/adhoc/creator/SGVyaW5ncywgUm9u|https://frl.publisso.de/adhoc/creator/THVjY2hpLCBTaWx2aWE=|https://frl.publisso.de/adhoc/creator/Um9taW8sIFNpbHZhbmE=|https://frl.publisso.de/adhoc/creator/U2NoYWRlLCBSZW7DqQ==|https://frl.publisso.de/adhoc/creator/U2NodWVtaWUsIE1hcnRpam4gSi4=|https://frl.publisso.de/adhoc/creator/U3RyYWF0bWFuLCBIdXVi|https://frl.publisso.de/adhoc/creator/VmFsa2hvZmYsIFZlcmE=|https://frl.publisso.de/adhoc/creator/VmlsbGEsIE1hcmNv|https://frl.publisso.de/adhoc/creator/U3R1cmtlbmJvb20sIE1pcmlhbQ==|https://frl.publisso.de/adhoc/creator/R2FyYmUsIEVkZWx0cmF1dA==
1000 Herausgeber/in
1000 Förderer
  1. European Community
  2. Leibniz Association
1000 Fördernummer
  1. 223495 (the SOS project)
  2. -
1000 Förderprogramm
  1. Seventh Framework Programme
  2. Open Access Fund
1000 Dateien
  1. Risk of ischemic stroke and the use of individual non-steroidal anti-inflammatory drugs: A multi-country European database study within the SOS Project
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410331.rdf
1000 Erstellt am 2018-10-01T14:14:40.798+0200
1000 Erstellt von 266
1000 beschreibt frl:6410331
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Fri Oct 05 15:37:16 CEST 2018
1000 Objekt bearb. Fri Oct 05 15:37:02 CEST 2018
1000 Vgl. frl:6410331
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410331 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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