1000 Titel
  • PBMC transcriptomic responses to primary and secondary vaccination differ due to divergent lean growth and antibody titers in a pig model
1000 Autor/in
  1. Adler, Marcel |
  2. Muráni, Eduard |
  3. Ponsuksili, Siriluck |
  4. Wimmers, Klaus |
1000 Erscheinungsjahr 2015
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-07-14
1000 Erschienen in
1000 Quellenangabe
  • 47(10): 470-478
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593825/ |
  • https://dx.doi.org/10.1152/physiolgenomics.00015.2015 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The genetic relationship between immune responsiveness and performance is not well understood, but a major topic of the evolution of resource allocation and of relevance in human medicine and livestock breeding, for instance. This study aims to show differences of transcript abundance changes during the time intervals before and after two tetanus toxoid (TT) vaccinations in domestic pigs differing in lean growth (LG) and anti-TT-antibody titers (AB) parameters of performance and immunocompetence. During response to the first vaccination all animals had a general decrease in transcript abundances related to various functional pathways as measured by comparative Affymetrix microarray hybridization and Ingenuity Pathway analyses. Low-AB phenotypes had predominantly decreased immune response transcripts. Combined phenotypes high-AB/high-LG had decreased transcripts related to growth factor signaling pathways. However, during the interval after the booster vaccination, high-LG and high-AB animals responded exclusively with increased immune transcripts, such as B-cell receptor signaling and cellular immune response pathways. In addition, high-LG and low-AB animals had predominantly increased transcripts of several cellular immune response pathways. Conversely, low-LG and high-AB animals had few elevated immune transcripts and decreased transcripts related to only two nonimmune-specific pathways. In response to booster vaccination high-LG phenotypes revealed enriched transcripts related to several different immune response pathways, regardless of AB phenotype. Different from the expected impact of AB titers, divergent AB phenotypes did not reflect considerable differences between immune transcripts. However, highly significant differences observed among divergent LG phenotypes suggest the compatibility of high performance and high vaccine responses.
1000 Sacherschließung
lokal immune response
lokal leukocytes
lokal microarray
lokal performance
lokal pathway analysis
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/QWRsZXIsIE1hcmNlbA==|https://frl.publisso.de/adhoc/creator/TXVyw6FuaSwgRWR1YXJk|https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1Y2s=|http://orcid.org/0000-0002-9523-6790
1000 Label
1000 Förderer
  1. German Federal Ministry of Education and Research (BMBF) |
1000 Fördernummer
  1. FKZ 0315536G; FKZ 0315130 A
1000 Förderprogramm
  1. AgroCluster Phänomics; FUGATO plus
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Education and Research (BMBF) |
    1000 Förderprogramm AgroCluster Phänomics; FUGATO plus
    1000 Fördernummer FKZ 0315536G; FKZ 0315130 A
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410493.rdf
1000 Erstellt am 2018-10-10T14:47:33.420+0200
1000 Erstellt von 122
1000 beschreibt frl:6410493
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Tue May 31 17:11:34 CEST 2022
1000 Objekt bearb. Tue May 31 17:11:33 CEST 2022
1000 Vgl. frl:6410493
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410493 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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