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WeightNameValue
1000 Titel
  • Siglecs: A journey through the evolution of sialic acid-binding immunoglobulin-type lectins
1000 Autor/in
  1. Bornhöfft, Kim F. |
  2. Goldammer, Tom |
  3. Rebl, Alexander |
  4. Galuska, Sebastian P. |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-05-08
1000 Erschienen in
1000 Quellenangabe
  • 86: 219-231
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.dci.2018.05.008 |
1000 Ergänzendes Material
  • https://www.sciencedirect.com/science/article/pii/S0145305X18301393?via%3Dihub#appsec1 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Siglecs (sialic acid-binding immunoglobulin-type lectins) are a family of immune regulatory receptors predominantly found on the cells of the hematopoietic system. A V-set Ig-like domain mediates the recognition of different sialylated glycoconjugates, which can lead to the activation or inhibition of the immune response, depending on the involved Siglecs. Siglecs are categorized into two subgroups: one including all CD33-related Siglecs and the other consisting of Siglec-1 (Sialoadhesin), Siglec-2 (CD22), Siglec-4 (myelin-associated glycoprotein, MAG) and Siglec-15. In contrast to the members of the CD33-related Siglecs, which share ∼50–99% sequence identity, Siglecs of the other subgroup show quite low homology (approximately 25–30% sequence identity). Based on the published sequences and functions of Siglecs, we performed phylogenetic analyses and sequence alignments to reveal the conservation of Siglecs throughout evolution. Therefore, we focused on the presence of Siglecs in different classes of vertebrates (fishes, amphibians, birds, reptiles and mammals), offering a bridge between the presence of different Siglecs and the biological situations of the selected animals.
1000 Sacherschließung
lokal Lectin
lokal ITAM
lokal Siglecs
lokal Vertebrate evolution
lokal Sialic acids
lokal ITIM
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/Qm9ybmjDtmZmdCwgS2ltIEYu|http://orcid.org/0000-0003-1215-5504|http://orcid.org/0000-0002-2918-7433|http://orcid.org/0000-0001-5565-0252
1000 Label
1000 Förderer
  1. European Union (EU)
  2. Ministry of Agriculture and the Environment in Mecklenburg–Western Pomerania, Germany
1000 Fördernummer
  1. MV-II.1-LM-004
  2. MV-II.1-LM-004
1000 Förderprogramm
  1. European Maritime and Fisheries Fund (EMFF)
  2. -
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410569.rdf
1000 Erstellt am 2018-10-15T11:19:01.915+0200
1000 Erstellt von 122
1000 beschreibt frl:6410569
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Thu Jan 30 19:17:50 CET 2020
1000 Objekt bearb. Mon Oct 15 11:20:13 CEST 2018
1000 Vgl. frl:6410569
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410569 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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