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WeightNameValue
1000 Titel
  • Under control: The innate immunity of fish from the inhibitors' perspective
1000 Autor/in
  1. Rebl, Alexander |
  2. Goldammer, Tom |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-04-06
1000 Erschienen in
1000 Quellenangabe
  • 77: 328-349
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.fsi.2018.04.016 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The innate immune response involves a concerted network of induced gene products, preformed immune effectors, biochemical signalling cascades and specialised cells. However, the multifaceted activation of these defensive measures can derail or overshoot and, if left unchecked, overwhelm the host. A plenty of regulatory devices therefore mediate the fragile equilibrium between pathogen defence and pathophysiological manifestations. Over the past decade in particular, an almost complete set of teleostean sequences orthologous to mammalian immunoregulatory factors has been identified in various fish species, which prove the remarkable conservation of innate immune-control concepts among vertebrates. This review will present the current knowledge on more than 50 teleostean regulatory factors (plus additional fish-specific paralogs) that are of paramount importance for controlling the clotting cascade, the complement system, pattern-recognition pathways and cytokine-signalling networks. A special focus lies on those immunoregulatory features that have emerged as potential biomarker genes in transcriptome-wide research studies. Moreover, we report on the latest progress in elucidating control elements that act directly with immune-gene-encoding nucleic acids, such as transcription factors, hormone receptors and micro- and long noncoding RNAs. Investigations into the function of teleostean inhibitory factors are still mainly based on gene-expression profiling or overexpression studies. However, in support of structural and in-vitro analyses, evidence from in-vivo trials is also available and revealed many biochemical details on piscine immune regulation. The presence of multiple gene copies in fish adds a degree of complexity, as it is so far hardly understood if they might play distinct roles during inflammation. The present review addresses this and other open questions that should be tackled by fish immunologists in future.
1000 Sacherschließung
lokal Decoy receptors
lokal Resolution of inflammation
lokal Inhibitory factors
lokal Innate immunity
lokal Toll-like receptor signalling
lokal Anti-inflammatory cytokines
lokal Stress hormones
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0002-2918-7433|http://orcid.org/0000-0003-1215-5504
1000 Label
1000 Förderer
  1. European Union (EU) |
  2. inistry of Agriculture, the Environment and Consumer Protection Mecklenburg-Western Pomerania/Germany |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. European Maritime and Fisheries Fund (EMFF); MoMV project
  2. MoMV project
1000 Dateien
  1. Under control: The innate immunity of fish from the inhibitors' perspective
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Union (EU) |
    1000 Förderprogramm European Maritime and Fisheries Fund (EMFF); MoMV project
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer inistry of Agriculture, the Environment and Consumer Protection Mecklenburg-Western Pomerania/Germany |
    1000 Förderprogramm MoMV project
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410571.rdf
1000 Erstellt am 2018-10-15T12:00:18.251+0200
1000 Erstellt von 122
1000 beschreibt frl:6410571
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Tue May 31 17:09:19 CEST 2022
1000 Objekt bearb. Tue May 31 17:09:18 CEST 2022
1000 Vgl. frl:6410571
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410571 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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