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[14796805 - Journal of Endocrinology] Hepatic thyroid signaling of heat-stressed late pregnant and early lactating cows.pdf 1,27MB
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1000 Titel
  • Hepatic thyroid signaling of heat-stressed late pregnant and early lactating cows
1000 Autor/in
  1. Weitzel, Joachim M. |
  2. Viergutz, Torsten |
  3. Albrecht, Dirk |
  4. Bruckmaier, Rupert |
  5. Schmicke, Marion |
  6. Tuchscherer, Armin |
  7. Koch, Franziska |
  8. Kuhla, Björn |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-05-12
1000 Erschienen in
1000 Quellenangabe
  • 234(2): 129-141
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.1530/JOE-17-0066 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516449/ |
1000 Ergänzendes Material
  • https://joe.bioscientifica.com/view/journals/joe/234/2/JOE-17-0066.xml#container-6340-item-6342 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • During the transition between late gestation and early lactation, dairy cows experience severe metabolic stress due to the high energy and nutrient requirements of the fetus and the mammary gland. Additional thermal stress that occurs with rising temperatures during the ongoing climate change has further adverse implications on energy intake, metabolism and welfare. The thyroid hormone (TH)-mediated cellular signaling has a pivotal role in regulation of body temperature, energy intake and metabolic adaptation to heat. To distinguish between energy intake and heat stress-related effects, Holstein cows were first kept at thermoneutrality at 15°C followed by exposure to heat stress (HS) at 28°C or pair-feeding (PF) at 15°C for 6 days, in late pregnancy and again in early lactation. Herein, we focused on hepatic metabolic changes associated with alterations in the hypothalamic–pituitary–thyroid axis in HS and PF animals. T3 and T4 levels dropped with HS or PF; however, in HS animals, this decline was more pronounced. Thyroid-stimulating hormone (TSH) levels remain unaffected, while plasma cholesterol concentrations were lower in HS than PF animals. Hepatic marker genes for TH action (THRA, DIO1 and PPARGC1) decreased after HS and were lower compared to PF cows but only post-partum. Proteomics data revealed reduced hepatic amino acid catabolism ante-partum and a shift toward activated beta-oxidation and gluconeogenesis but declined oxidative stress defense post-partum. Thus, liver metabolism of HS and PF cows adapts differently to diminished energy intake both ante-partum and post-partum, and a different TH sensitivity is involved in the regulation of catabolic processes.
1000 Sacherschließung
lokal thyroid-stimulating hormone
lokal heat stress
lokal dairy cow
lokal thyroid hormone metabolism
lokal liver
1000 Fachgruppe
  1. Biologie |
  2. Agrarwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/V2VpdHplbCwgSm9hY2hpbSBNLg==|https://frl.publisso.de/adhoc/creator/Vmllcmd1dHosIFRvcnN0ZW4=|https://frl.publisso.de/adhoc/creator/QWxicmVjaHQsIERpcms=|https://frl.publisso.de/adhoc/creator/QnJ1Y2ttYWllciwgUnVwZXJ0|https://frl.publisso.de/adhoc/creator/U2NobWlja2UsIE1hcmlvbg==|https://frl.publisso.de/adhoc/creator/VHVjaHNjaGVyZXIsIEFybWlu|https://frl.publisso.de/adhoc/creator/S29jaCwgRnJhbnppc2th|https://frl.publisso.de/adhoc/creator/S3VobGEsIEJqw7Zybg==
1000 Label
1000 Förderer
  1. Leibniz Institute for Farm Animal Biology (FBN)
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
  1. Hepatic thyroid signaling of heat-stressed late pregnant and early lactating cows
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410583.rdf
1000 Erstellt am 2018-10-16T09:50:01.393+0200
1000 Erstellt von 122
1000 beschreibt frl:6410583
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet 2020-01-30T19:18:23.834+0100
1000 Objekt bearb. Wed Oct 17 11:27:24 CEST 2018
1000 Vgl. frl:6410583
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410583 |
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