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1000 Titel
  • Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD‐deficient IGFBP‐2 variant in female transgenic mice
1000 Autor/in
  1. Hoeflich, Andreas |
  2. Reyer, Anja |
  3. Ohde, Daniela |
  4. Schindler, Nancy |
  5. Brenmoehl, Julia |
  6. Spitschak, Marion |
  7. Langhammer, Martina |
  8. Tuchscherer, Armin |
  9. Wirthgen, Elisa |
  10. Renner-Müller, Ingrid |
  11. Wanke, Rüdiger |
  12. Metzger, Friedrich |
  13. Bielohuby, Maximilian |
  14. Wolf, Eckhard |
1000 Erscheinungsjahr 2015
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-10-28
1000 Erschienen in
1000 Quellenangabe
  • 15(1): 111-117
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1111/acel.12413 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717279/ |
1000 Ergänzendes Material
  • https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12413#support-information-section |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Impaired growth is often associated with an extension of lifespan. However, the negative correlation between somatic growth and life expectancy is only true within, but not between, species. This can be observed because smaller species have, as a rule, a shorter lifespan than larger species. In insects and worms, reduced reproductive development and increased fat storage are associated with prolonged lifespan. However, in mammals the relationship between the dynamics of reproductive development, fat metabolism, growth rate, and lifespan are less clear. To address this point, female transgenic mice that were overexpressing similar levels of either intact (D‐mice) or mutant insulin‐like growth factor‐binding protein‐2 (IGFBP‐2) lacking the Arg‐Gly‐Asp (RGD) motif (E‐ mice) were investigated. Both lines of transgenic mice exhibited a similar degree of growth impairment (−9% and −10%) in comparison with wild‐type controls (C‐mice). While in D‐mice, sexual maturation was found to be delayed and life expectancy was significantly increased in comparison with C‐mice, these parameters were unaltered in E‐mice in spite of their reduced growth rate. These observations indicate that the RGD‐domain has a major influence on the pleiotropic effects of IGFBP‐2 and suggest that somatic growth and time of sexual maturity or somatic growth and life expectancy are less closely related than thought previously.
1000 Sacherschließung
lokal IGFBP-2
lokal cell signaling
lokal groth
lokal AKT
lokal aging
lokal reproductive development
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0003-2018-2836|https://frl.publisso.de/adhoc/creator/UmV5ZXIsIEFuamE=|https://frl.publisso.de/adhoc/creator/T2hkZSwgRGFuaWVsYQ==|https://frl.publisso.de/adhoc/creator/U2NoaW5kbGVyLCBOYW5jeQ==|https://frl.publisso.de/adhoc/creator/QnJlbm1vZWhsLCBKdWxpYQ==|https://frl.publisso.de/adhoc/creator/U3BpdHNjaGFrLCBNYXJpb24=|https://frl.publisso.de/adhoc/creator/TGFuZ2hhbW1lciwgTWFydGluYQ==|https://frl.publisso.de/adhoc/creator/VHVjaHNjaGVyZXIsIEFybWlu|https://frl.publisso.de/adhoc/creator/V2lydGhnZW4sIEVsaXNh|https://frl.publisso.de/adhoc/creator/UmVubmVyLU3DvGxsZXIsIEluZ3JpZCA=|https://frl.publisso.de/adhoc/creator/V2Fua2UsIFLDvGRpZ2Vy|https://frl.publisso.de/adhoc/creator/TWV0emdlciwgRnJpZWRyaWNo|https://frl.publisso.de/adhoc/creator/QmllbG9odWJ5LCBNYXhpbWlsaWFu|https://frl.publisso.de/adhoc/creator/V29sZiwgRWNraGFyZA==
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft (DFG) |
  2. H. Wilhelm Schaumann Stiftung. |
1000 Fördernummer
  1. HO 2003/6‐1
  2. -
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer HO 2003/6‐1
  2. 1000 joinedFunding-child
    1000 Förderer H. Wilhelm Schaumann Stiftung. |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410692.rdf
1000 Erstellt am 2018-10-22T11:09:06.873+0200
1000 Erstellt von 122
1000 beschreibt frl:6410692
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 21:57:21 CET 2020
1000 Objekt bearb. Thu Jan 17 13:32:40 CET 2019
1000 Vgl. frl:6410692
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410692 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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