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1000 Titel
  • Current IGFBP-Related Biomarker Research in Cardiovascular Disease—We Need More Structural and Functional Information in Clinical Studies
1000 Autor/in
  1. Hoeflich, Andreas |
  2. Hoeflich, Andreas |
  3. David, Robert |
  4. Hjortebjerg, Rikke |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-07-16
1000 Erschienen in
1000 Quellenangabe
  • 9:388
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fendo.2018.00388 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054974/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Cardiovascular diseases are the leading cause of death around the world and the insulin-like growth factor (IGF)-system has multiple functions for the pathological conditions of atherosclerosis. IGF binding proteins (IGFBPs) are widely investigated as biomarkers for pathological disorders, including those of the heart. At the tissue level, IGFBP-1 to -6 decrease bioactivity of IGF-I and -II due to their high affinity IGF-binding sites. By contrast, in the circulation, the IGFBPs increase biological half-life of the IGFs and may therefore be regarded as positive regulators of IGF-effects. The IGFBPs may also exert IGF-independent functions inside or outside the cell. Importantly, the circulating IGFBP-concentrations are regulated by trophic, metabolic, and reproductive hormones. In a multitude of studies of healthy subjects and patients with coronary heart diseases, various significant associations between circulating IGFBP-levels and defined parameters have been reported. However, the complex hormonal and conditional control of IGFBPs may explain the lack of clear associations between IGFBPs and parameters of cardiac failure in broader studies including larger populations. Furthermore, the IGFBPs are subject to posttranslational modifications and proteolytic degradation by proteases, upon which the IGFs are released. In this review, we emphasize that, with the exception of IGFBP-4 and in sharp contrast to the preclinical studies, virtually all clinical studies do not have structural or functional information on their biomarker. The use of analytical systems with no discriminatory potential toward intact vs. fragmented IGFBPs represents a major issue in IGFBP-related biomarker research and an important focus point for the future. Overall, measurements of selected IGFBPs or more complex IGFBP-signatures of the family of IGFBPs have potential to identify pathophysiological alterations in the heart or patients with high cardiovascular risk, particularly if defined cohorts are to be assessed. However, a more thorough understanding of the dynamic IGF-IGFBP system as well as its proteases and protease inhibitors in both normal physiology and in cardiovascular diseases is necessary.
1000 Sacherschließung
lokal IGFBP
lokal PAPP-A
lokal mortality
lokal IGF
lokal diseases
lokal IGFBP-fragment
lokal cardiovascular
1000 Fachgruppe
  1. Medizin |
  2. Gesundheitswesen |
  3. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0003-2018-2836|https://frl.publisso.de/adhoc/creator/SG9lZmxpY2gsIEFuZHJlYXM=|https://frl.publisso.de/adhoc/creator/RGF2aWQsIFJvYmVydA==|https://frl.publisso.de/adhoc/creator/SGpvcnRlYmplcmcsIFJpa2tl
1000 Label
1000 Förderer
  1. Danish Diabetes Academy |
  2. Novo Nordisk Foundation |
  3. Rostock University Medical Centre |
  4. DAMP Foundation and |
  5. Federal Ministry of Education and Research (BMBF) |
1000 Fördernummer
  1. -
  2. -
  3. -
  4. -
  5. VIP+00240
1000 Förderprogramm
  1. -
  2. -
  3. FORUN Program
  4. -
  5. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Danish Diabetes Academy |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Novo Nordisk Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Rostock University Medical Centre |
    1000 Förderprogramm FORUN Program
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer DAMP Foundation and |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Federal Ministry of Education and Research (BMBF) |
    1000 Förderprogramm -
    1000 Fördernummer VIP+00240
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410754.rdf
1000 Erstellt am 2018-10-24T14:16:38.387+0200
1000 Erstellt von 122
1000 beschreibt frl:6410754
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 19:19:59 CET 2020
1000 Objekt bearb. Tue Dec 18 12:41:08 CET 2018
1000 Vgl. frl:6410754
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410754 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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