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WeightNameValue
1000 Titel
  • On Estimation of Genome Composition in Genetically Admixed Individuals Using Constrained Genomic Regression
1000 Autor/in
  1. Boerner, Vinzent |
  2. Wittenburg, Dörte |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-05-07
1000 Erschienen in
1000 Quellenangabe
  • 9:185
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fgene.2018.00185 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986875/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Quantifying the population stratification in genotype samples has become a standard procedure for data manipulation before conducting genome wide association studies, as well as for tracing patterns of migration in humans and animals, and for inference about extinct founder populations. The most widely used approach capable of providing biologically interpretable results is a likelihood formulation which allows for estimation of founder genome proportions and founder allele frequency conditional on the observed genotypes. However, if founder allele frequencies are known and samples are dominated by admixed genotypes this approach may lead to biased inference. In addition, processing time increases drastically with the number of genetic markers. This article describes a simplified approach for obtaining biologically meaningful measures of population stratification at the genotype level conditional on known founder allele frequencies. It was tested on cattle and human data sets with 4,022 and 150,000 genetic markers, respectively, and proved to be very accurate in situations where founder poplations were correctly specified, or under-, over-, and miss-specified. Moreover, processing time was only marginally affected by an increase in the number of markers.
1000 Sacherschließung
lokal estimation
lokal genome
lokal admixture
lokal stratification
lokal regression
lokal constrained
lokal population
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/Qm9lcm5lciwgVmluemVudA==|http://orcid.org/0000-0002-3639-2574
1000 Label
1000 Förderer
  1. Meat and Livestock Australia |
1000 Fördernummer
  1. B.BFG.0050
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Meat and Livestock Australia |
    1000 Förderprogramm -
    1000 Fördernummer B.BFG.0050
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410761.rdf
1000 Erstellt am 2018-10-25T10:30:52.608+0200
1000 Erstellt von 122
1000 beschreibt frl:6410761
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 19:20:35 CET 2020
1000 Objekt bearb. Tue Dec 18 12:39:59 CET 2018
1000 Vgl. frl:6410761
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410761 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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