WeightNameValue
1000 Titel
  • Ubiquinol affects the expression of genes involved in PPARα signalling and lipid metabolism without changes in methylation of CpG promoter islands in the liver of mice
1000 Autor/in
  1. Schmelzer, Constance |
  2. Kitano, Mitsuaki |
  3. Hosoe, Kazunori |
  4. Döring, Frank |
1000 Erscheinungsjahr 2011
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2011-11-11
1000 Erschienen in
1000 Quellenangabe
  • 50(2): 119-126
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303474/ |
  • https://doi.org/10.3164/jcbn.11-19 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Coenzyme Q10 is an essential cofactor in the respiratory chain and serves as a potent antioxidant in biological membranes. Recent studies in vitro and in vivo provide evidence that Coenzyme Q10 is involved in inflammatory processes and lipid metabolism via gene expression. To study these effects at the epigenomic level, C57BL6J mice were supplemented for one week with reduced Coenzyme Q10 (ubiquinol). Afterwards, gene expression signatures and DNA promoter methylation patterns of selected genes were analysed. Genome-wide transcript profiling in the liver identified 1112 up-regulated and 571 down-regulated transcripts as differentially regulated between ubiquinol-treated and control animals. Text mining and GeneOntology analysis revealed that the ”top 20” ubiquinol-regulated genes play a role in lipid metabolism and are functionally connected by the PPARα signalling pathway. With regard to the ubiquinol-induced changes in gene expression of about +3.14-fold (p≤0.05), +2.18-fold (p≤0.01), and −2.13-fold (p≤0.05) for ABCA1, ACYP1, and ACSL1 genes, respectively, hepatic DNA methylation analysis of 282 (sense orientation) and 271 (antisense) CpG units in the respective promoter islands revealed no significant effect of ubiquinol. In conclusion, ubiquinol affects the expression of genes involved in PPARα signalling and lipid metabolism without changing the promoter DNA methylation status in the liver of mice.
1000 Sacherschließung
lokal inflammation
lokal methylation
lokal lipid metabolism
lokal gene expression
lokal ubiquinol
1000 Fachgruppe
  1. Biologie |
  2. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/U2NobWVsemVyLCBDb25zdGFuY2U=|https://frl.publisso.de/adhoc/creator/S2l0YW5vLCBNaXRzdWFraQ==|https://frl.publisso.de/adhoc/creator/SG9zb2UsIEthenVub3Jp|https://frl.publisso.de/adhoc/creator/RMO2cmluZywgRnJhbms=
1000 Label
1000 Förderer
  1. KANEKA Corporation
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410814.rdf
1000 Erstellt am 2018-10-26T09:34:25.207+0200
1000 Erstellt von 122
1000 beschreibt frl:6410814
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 16:59:45 CET 2020
1000 Objekt bearb. Thu Jan 17 13:27:12 CET 2019
1000 Vgl. frl:6410814
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410814 |
1000 Sichtbarkeit Metadaten public
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