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WeightNameValue
1000 Titel
  • Effects of cranberry extracts on gene expression in THP‐1 cells
1000 Autor/in
  1. Hannon, Daniel B. |
  2. Thompson, Jerry T. |
  3. Khoo, Christina |
  4. Juturu, Vijaya |
  5. Vanden Heuvel, John P. |
1000 Erscheinungsjahr 2016
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-04-25
1000 Erschienen in
1000 Quellenangabe
  • 5(1):148-159
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/fsn3.374 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217924/ |
1000 Ergänzendes Material
  • https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.374 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Cranberry contains high levels of nutrients and bioactive molecules that have health‐promoting properties. The purpose of the present studies was to determine if cranberry extracts (CEs) contain phytochemicals that exert anti‐inflammatory effects. The human monocytic cell line THP‐1 was treated with two CEs (CE and 90MX) and subsequently challenged with Lipopolysaccharides (LPS). Tumor necrosis factor α (TNFα) expression was decreased in the CE‐treated cells, indicative of an anti‐inflammatory effect. Gene expression microarrays identified several immune‐related genes that were responsive to CEs including interferon‐induced protein with tetratricopeptide repeats 1 and 3 (IFIT 1 and 3), macrophage scavenger receptor 1 (MSR1) and colony‐stimulating factor 2 (CSF2). In addition, in the CE‐treated cells, metallothionein 1F and other metal‐responsive genes were induced. Taken together, this data indicates that CEs contain bioactive components that have anti‐inflammatory effects and may protect cells from oxidative damage.
1000 Sacherschließung
lokal proanthocyanidins
lokal reactive oxygen species
lokal nutrigenomics
lokal macrophage
lokal Gene expression
1000 Fachgruppe
  1. Ernährungswissenschaften |
  2. Gesundheitswesen |
  3. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SGFubm9uLCBEYW5pZWwgQi4=|https://frl.publisso.de/adhoc/creator/VGhvbXBzb24sIEplcnJ5IFQu|https://frl.publisso.de/adhoc/creator/S2hvbywgQ2hyaXN0aW5h|https://frl.publisso.de/adhoc/creator/SnV0dXJ1LCBWaWpheWE=|https://frl.publisso.de/adhoc/creator/VmFuZGVuIEhldXZlbCwgSm9obiBQLg==
1000 Dateien
  1. Effects of cranberry extracts on gene expression in THP‐1 cells
1000 Objektart article
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1000 Erstellt am 2018-11-20T14:17:15.084+0100
1000 Erstellt von 286
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1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Mon Jan 07 13:15:40 CET 2019
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1000 Vgl. frl:6411235
1000 Oai Id
  1. oai:frl.publisso.de:frl:6411235 |
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