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1000 Titel
  • Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet
1000 Autor/in
  1. Yoneda, Toshiki |
  2. Tomofuji, Takaaki |
  3. Kunitomo, Muneyoshi |
  4. Ekuni, Daisuke |
  5. Irie, Koichiro |
  6. Azuma, Tetsuji |
  7. Machida, Tatsuya |
  8. Miyai, Hisataka |
  9. Fujimori, Kouhei |
  10. Morita, Manabu |
1000 Erscheinungsjahr 2017
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-01-13
1000 Erschienen in
1000 Quellenangabe
  • 9(1):64
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.3390/nu9010064 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295108/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Obesity induces gingival oxidative stress, which is involved in the progression of alveolar bone resorption. The antioxidant effect of hydrogen-rich water may attenuate gingival oxidative stress and prevent alveolar bone resorption in cases of obesity. We examined whether hydrogen-rich water could suppress gingival oxidative stress and alveolar bone resorption in obese rats fed a high-fat diet. Male Fischer 344 rats (n = 18) were divided into three groups of six rats each: a control group (fed a regular diet and drinking distilled water) and two experimental groups (fed a high-fat diet and drinking distilled water or hydrogen-rich water). The level of 8-hydroxydeoxyguanosine was determined to evaluate oxidative stress. The bone mineral density of the alveolar bone was analyzed by micro-computerized tomography. Obese rats, induced by a high-fat diet, showed a higher gingival level of 8-hydroxydeoxyguanosine and a lower level of alveolar bone density compared to the control group. Drinking hydrogen-rich water suppressed body weight gain, lowered gingival level of 8-hydroxydeoxyguanosine, and reduced alveolar bone resorption in rats on a high-fat diet. The results indicate that hydrogen-rich water could suppress gingival oxidative stress and alveolar bone resorption by limiting obesity.
1000 Sacherschließung
lokal alveolar bone loss
lokal animal disease model
lokal hydrogen-rich water
lokal obesity
lokal oxidative stress
1000 Fachgruppe
  1. Ernährungswissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/WW9uZWRhLCBUb3NoaWtp|https://frl.publisso.de/adhoc/creator/VG9tb2Z1amksIFRha2Fha2k=|https://frl.publisso.de/adhoc/creator/S3VuaXRvbW8sIE11bmV5b3NoaQ==|http://orcid.org/0000-0002-1876-5605|https://frl.publisso.de/adhoc/creator/SXJpZSwgS29pY2hpcm8=|https://frl.publisso.de/adhoc/creator/QXp1bWEsIFRldHN1amk=|https://frl.publisso.de/adhoc/creator/TWFjaGlkYSwgVGF0c3V5YQ==|https://frl.publisso.de/adhoc/creator/TWl5YWksIEhpc2F0YWth|https://frl.publisso.de/adhoc/creator/RnVqaW1vcmksIEtvdWhlaQ==|https://frl.publisso.de/adhoc/creator/TW9yaXRhLCBNYW5hYnU=
1000 Label
1000 Förderer
  1. Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan
1000 Fördernummer
  1. 16K11855;16K11856; 16K20693
1000 Förderprogramm
  1. -
1000 Dateien
1000 Objektart article
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1000 Erstellt am 2018-12-10T11:40:30.106+0100
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1000 Zuletzt bearbeitet 2020-01-31T00:40:45.125+0100
1000 Objekt bearb. Tue Dec 11 09:50:58 CET 2018
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