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1000 Titel
  • The Root Extract of Pueraria lobata and Its Main Compound, Puerarin, Prevent Obesity by Increasing the Energy Metabolism in Skeletal Muscle
1000 Autor/in
  1. Jung, Hyo Won |
  2. Kang, An Kang |
  3. Kang, Seok Yong |
  4. Park, Yong-Ki |
  5. Song, Mi Young |
1000 Erscheinungsjahr 2017
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-01-04
1000 Erschienen in
1000 Quellenangabe
  • 9(1):33
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.3390/nu9010033 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295077/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Radix Pueraria lobata (RP) has been reported to prevent obesity and improve glucose metabolism; however, the mechanism responsible for these effects has not been elucidated. The mechanism underlying anti-obesity effect of RP was investigated in high-fat diet (HFD) induced obese mice and skeletal muscle cells (C2C12). Five-week-old C5BL/6 mice were fed a HFD containing or not containing RP (100 or 300 mg/kg) or metformin (250 mg/kg) for 16 weeks. RP reduced body weight gain, lipid accumulation in liver, and adipocyte and blood lipid levels. In addition, RP dose-dependently improved hyperglycemia, insulinemia, and glucose tolerance, and prevented the skeletal muscle atrophy induced by HFD. Furthermore, RP increased the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) expression and phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) in skeletal muscle tissues. RP and its main component, puerarin, increased mitochondrial biogenesis and myotube hypertrophy in C2C12 cells. The present study demonstrates that RP can prevent diet-induced obesity, glucose tolerance, and skeletal muscle atrophy in mouse models of obesity. The mechanism responsible for the effect of RP appears to be related to the upregulation of energy metabolism in skeletal muscle, which at the molecular level may be associated with PGC-1α and AMPK activation.
1000 Sacherschließung
lokal Radix Pueraria lobata
lokal C2C12
lokal puerarin
lokal AMPK
lokal PGC-1α
lokal skeletal muscle
lokal obesity
1000 Fachgruppe
  1. Medizin |
  2. Ernährungswissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SnVuZywgSHlvIFdvbg==|https://frl.publisso.de/adhoc/creator/S2FuZywgQW4gS2FuZw==|https://frl.publisso.de/adhoc/creator/S2FuZywgU2VvayBZb25n|https://frl.publisso.de/adhoc/creator/UGFyaywgWW9uZy1LaQ==|https://frl.publisso.de/adhoc/creator/U29uZywgTWkgWW91bmc=
1000 Förderer
  1. Ministry of Health & Welfare, Republic of Korea |
1000 Fördernummer
  1. HI15C0127
1000 Förderprogramm
  1. Korean Health Technology R&D Project
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Ministry of Health & Welfare, Republic of Korea |
    1000 Förderprogramm Korean Health Technology R&D Project
    1000 Fördernummer HI15C0127
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6411824.rdf
1000 Erstellt am 2018-12-14T14:00:47.595+0100
1000 Erstellt von 122
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1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Fri Dec 14 14:02:57 CET 2018
1000 Objekt bearb. Fri Dec 14 14:01:59 CET 2018
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1000 Oai Id
  1. oai:frl.publisso.de:frl:6411824 |
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