1-s2.0-S2213453016301392-main.pdf 2,06MB
1000 Titel
  • Comparison of chicoric acid, and its metabolites caffeic acid and caftaric acid: In vitro protection of biological macromolecules and inflammatory responses in BV2 microglial cells
1000 Autor/in
  1. Liu, Qian |
  2. Liu, Fan |
  3. Zhang, Liling |
  4. Niu, Yajie |
  5. Liu, Zhigang |
  6. Liu, Xuebo |
1000 Erscheinungsjahr 2017
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-09-23
1000 Erschienen in
1000 Quellenangabe
  • 6(4):155-166
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • |
1000 Ergänzendes Material
  • |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Chicoric acid (CA), a natural phenolic acid, has been used as a nutraceutical food ingredient due to its powerful antioxidant, anti-HIV and anti-diabetic bioactivities. CA could be partly metabolized into caffeic acid (CFA) and caftaric acid (CTA) on cytochrome P450s in rat liver microsomes. To compare the protective effects of CA and its metabolites on biomolecules and inflammatory responses, oxidative damage induced by free radicals in vitro and microglial inflammation triggered by lipopolysaccharide in BV2 cells were constructed. Results showed that CA, CTA and CFA all significantly inhibited protein degradation and carbonylation induced by hydroxyl radicals and alcoxyl radicals, and suppressed hemin/nitrite/H2O2 triggered-nitration. Moreover, CA, CTA and CFA all exerted remarkable inhibition capacities on linoleic acid and soybean lecithin liposomes peroxidation in a dose-dependent manner, and restrained the oxidation of herring sperm DNA, as well as the breakage of pBR322 plasmid DNA. Furthermore, CA and its metabolites suppressed lipopolysaccharide-induced decline of BV2 cell viability and the production of NO and ROS. However, bioactivities of CA were significantly stronger than those of its metabolites within a certain concentration range. This study provides scientific basis for the application of CA and its metabolites as nutrition and natural antioxidants.
1000 Sacherschließung
lokal Oxidative damage
lokal Biomolecules
lokal Chicoric acid and its metabolites
lokal Inflammation
lokal Microglia
1000 Fachgruppe
  1. Medizin |
  2. Ernährungswissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
1000 Förderer
  1. People's Republic of China |
1000 Fördernummer
  1. 2016YFD0400601; 2014KTCL02-07
1000 Förderprogramm
  1. National Key Research and Development Program; Science and Technology Coordination Project of Innovation in Shaanxi Province
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer People's Republic of China |
    1000 Förderprogramm National Key Research and Development Program; Science and Technology Coordination Project of Innovation in Shaanxi Province
    1000 Fördernummer 2016YFD0400601; 2014KTCL02-07
1000 Objektart article
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1000 @id frl:6412158.rdf
1000 Erstellt am 2019-01-22T11:42:37.159+0100
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