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1000 Titel
  • An Exercise‐Only Intervention in Obese Fathers Restores Glucose and Insulin Regulation in Conjunction with the Rescue of Pancreatic Islet Cell Morphology and MicroRNA Expression in Male Offspring
1000 Autor/in
  1. McPherson, Nicole O. |
  2. Lane, Michelle |
  3. Sandeman, Lauren |
  4. Owens, Julie A. |
  5. Fullston, Tod |
1000 Erscheinungsjahr 2017
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-02-09
1000 Erschienen in
1000 Quellenangabe
  • 9(2):122
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.3390/nu9020122 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331553/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Paternal obesity programs metabolic syndrome in offspring. Low‐impact exercise in obese males improves the metabolic health of female offspring, however whether this occurred in male offspring remained unknown. C57BL/6NHsd (Harlan) mice were fed a control diet (CD; 6% fat, n = 7) or a high‐fat diet (HFD; 21% fat, n = 16) for 18 weeks. After 9 weeks, HFD‐fed mice either remained sedentary (HH, n = 8) or undertook low–moderate exercise (HE, n = 8) for another 9 weeks. Male offspring were assessed for glucose/insulin tolerance, body composition, plasma lipids, pancreatic islet cell morphology and microRNA expression. Founder HH induced glucose intolerance, insulin insensitivity, and hyperlipidaemia in male offspring (p < 0.05). Metabolic health was fully restored in male offspring by founder exercise to control levels. Founder HH reduced pancreatic β‐cell area and islet cell size in male offspring, and altered the expression of 13 pancreatic microRNAs (p < 0.05). Founder HE led to partial restoration of pancreatic islet cell morphology and the expression of two pancreatic microRNAs (let7d‐5p, 194‐5p) in male offspring. Founder HE reduced male offspring adiposity, increased muscle mass, reduced plasma free fatty acids (FFAs), and further altered pancreatic microRNAs (35 vs. HH; 32 vs. CD) (p < 0.05). Low‐impact exercise in obese fathers prior to conception, without dietary change, may be a viable intervention strategy to reduce the illeffects of obesity‐induced paternal programming in male offspring.
1000 Sacherschließung
lokal nutrition
lokal fertility
lokal sperm
1000 Fachgruppe
  1. Gesundheitswesen |
  2. Ernährungswissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/TWNQaGVyc29uLCBOaWNvbGUgTy4=|https://frl.publisso.de/adhoc/creator/TGFuZSwgTWljaGVsbGU=|https://frl.publisso.de/adhoc/creator/U2FuZGVtYW4sIExhdXJlbg==|https://frl.publisso.de/adhoc/creator/T3dlbnMsIEp1bGllIEEu|https://frl.publisso.de/adhoc/creator/RnVsbHN0b24sIFRvZA==
1000 Label
1000 Förderer
  1. NHMRC
  2. Diabetes Australia Research Trust
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6412427.rdf
1000 Erstellt am 2019-01-30T11:33:08.048+0100
1000 Erstellt von 122
1000 beschreibt frl:6412427
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet 2020-01-30T22:13:11.415+0100
1000 Objekt bearb. Wed Jan 30 11:33:53 CET 2019
1000 Vgl. frl:6412427
1000 Oai Id
  1. oai:frl.publisso.de:frl:6412427 |
1000 Sichtbarkeit Metadaten public
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