Impact of Flavonols on Cardiometabolic Biomarkers: A Meta‐Analysis of Randomized Controlled Human Trials to Explore the Role of Inter‐Individual Variability

  1. Menezes, Regina
  2. Rodriguez-Mateos, Ana
  3. Kaltsatou, Antonia
  4. González-Sarrías, Antonio ORCID logo
  5. Greyling, Arno
  6. Giannaki, Christoforos ORCID logo
  7. Andres-Lacueva, Cristina
  8. Milenkovic, Dragan
  9. Gibney, Eileen ORCID logo
  10. Dumont, Julie
  11. Schär, Manuel
  12. Garcia-Aloy, Mar ORCID logo
  13. Palma-Duran, Susana A ORCID logo
  14. Ruskovska, Tatjana ORCID logo
  15. Maksimova, Viktorija
  16. Combet, Emilie ORCID logo
  17. Pinto, Paula ORCID logo

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1000 Titel
  • Impact of Flavonols on Cardiometabolic Biomarkers: A Meta‐Analysis of Randomized Controlled Human Trials to Explore the Role of Inter‐Individual Variability
1000 Autor/in
  1. Menezes, Regina |
  2. Rodriguez-Mateos, Ana |
  3. Kaltsatou, Antonia |
  4. González-Sarrías, Antonio |
  5. Greyling, Arno |
  6. Giannaki, Christoforos |
  7. Andres-Lacueva, Cristina |
  8. Milenkovic, Dragan |
  9. Gibney, Eileen |
  10. Dumont, Julie |
  11. Schär, Manuel |
  12. Garcia-Aloy, Mar |
  13. Palma-Duran, Susana A |
  14. Ruskovska, Tatjana |
  15. Maksimova, Viktorija |
  16. Combet, Emilie |
  17. Pinto, Paula |
1000 Erscheinungsjahr 2017
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-02-09
1000 Erschienen in
1000 Quellenangabe
  • 9(2):117
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.3390/nu9020117 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331548/ |
1000 Ergänzendes Material
  • https://www.mdpi.com/2072-6643/9/2/117#supplementary |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Several epidemiological studies have linked flavonols with decreased risk of cardiovascular disease (CVD). However, some heterogeneity in the individual physiological responses to the consumption of these compounds has been identified. This meta‐analysis aimed to study the effect of flavonol supplementation on biomarkers of CVD risk such as, blood lipids, blood pressure and plasma glucose, as well as factors affecting their inter‐individual variability. Data from 18 human randomized controlled trials were pooled and the effect was estimated using fixed or random effects meta‐analysis model and reported as difference in means (DM). Variability in the response of blood lipids to supplementation with flavonols was assessed by stratifying various population subgroups: age, sex, country, and health status. Results showed significant reductions in total cholesterol (DM = −0.10 mmol/L; 95% CI: −0.20, −0.01), LDL cholesterol (DM = −0.14 mmol/L; Nutrients 2017, 9, 117 2 of 21 95% CI: −0.21, 0.07), and triacylglycerol (DM = −0.10 mmol/L; 95% CI: −0.18, 0.03), and a significant increase in HDL cholesterol (DM = 0.05 mmol/L; 95% CI: 0.02, 0.07). A significant reduction was also observed in fasting plasma glucose (DM = −0.18 mmol/L; 95%CI: −0.29, −0.08), and in blood pressure (SBP: DM = −4.84 mmHg; 95% CI: −5.64, −4.04; DBP: DM = −3.32 mmHg; 95% CI: -4.09, -2.55). Subgroup analysis showed a more pronounced effect of flavonol intake in participants from Asian countries and in participants with diagnosed disease or dyslipidemia, compared to healthy and normal baseline values. In conclusion, flavonol consumption improved biomarkers of CVD risk, however, country of origin and health status may influence the effect of flavonol intake on blood lipid levels
1000 Sacherschließung
lokal blood pressure
lokal cardiovascular disease
lokal glucose
lokal Interindividual variability
lokal flavonols
lokal meta-analysis
lokal quercetin
lokal systematic review
lokal blood lipids
1000 Fachgruppe
  1. Ernährungswissenschaften |
  2. Gesundheitswesen |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/TWVuZXplcywgUmVnaW5h|https://frl.publisso.de/adhoc/creator/Um9kcmlndWV6LU1hdGVvcywgQW5h|https://frl.publisso.de/adhoc/creator/S2FsdHNhdG91LCBBbnRvbmlh|http://orcid.org/0000-0002-3407-0678|https://frl.publisso.de/adhoc/creator/R3JleWxpbmcsIEFybm8=|http://orcid.org/0000-0003-0029-1189|https://frl.publisso.de/adhoc/creator/QW5kcmVzLUxhY3VldmEsIENyaXN0aW5h|https://frl.publisso.de/adhoc/creator/TWlsZW5rb3ZpYywgRHJhZ2Fu|http://orcid.org/0000-0001-9465-052X|https://frl.publisso.de/adhoc/creator/RHVtb250LCBKdWxpZQ==|https://frl.publisso.de/adhoc/creator/U2Now6RyLCBNYW51ZWw=|http://orcid.org/0000-0002-1330-6610|http://orcid.org/0000-0002-4210-3855|http://orcid.org/0000-0002-4300-4891|https://frl.publisso.de/adhoc/creator/TWFrc2ltb3ZhLCBWaWt0b3JpamE=|http://orcid.org/0000-0002-9302-8971|http://orcid.org/0000-0001-6379-1768
1000 Label
1000 Förderer
  1. European Union (EU)
  2. Spanish Ministry of Economy and Competitiveness (MINECO)
  3. Consejo Nacional de Ciencia y Tecnologia (CONACyT)
  4. Goce Delcev University
  5. Fundação para a Ciência e Tecnologia/Ministério da Ciência e do Ensino Superior
1000 Fördernummer
  1. FA1403—POSITIVe; PT2020
  2. -
  3. -
  4. -
  5. LISBOA-01-0145-FEDER-007344
1000 Förderprogramm
  1. COST Action; Interindividual variation in response to consumption of plant food bioactives and determinants involved; FEDER
  2. Juan de la Cierva; Joint Programming Initiative Healthy Diet for Healthy Life (JPI-HDHL)
  3. -
  4. -
  5. -
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6412433.rdf
1000 Erstellt am 2019-01-30T11:59:15.116+0100
1000 Erstellt von 122
1000 beschreibt frl:6412433
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Thu Jan 30 19:33:08 CET 2020
1000 Objekt bearb. Wed Jan 30 11:59:59 CET 2019
1000 Vgl. frl:6412433
1000 Oai Id
  1. oai:frl.publisso.de:frl:6412433 |
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