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1000 Titel
  • Lychee Seed Saponins Improve Cognitive Function and Prevent Neuronal Injury via Inhibiting Neuronal Apoptosis in a Rat Model of Alzheimer’s Disease
1000 Autor/in
  1. Wang, Xiuling |
  2. Wu, Jianming |
  3. Yu, Chonglin |
  4. Tang, Yong |
  5. Liu, Jian |
  6. Chen, Haixia |
  7. Jin, Bingjin |
  8. Mei, Qibing |
  9. Cao, Shousong |
  10. Qin, Dalian |
1000 Erscheinungsjahr 2017
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-02-04
1000 Erschienen in
1000 Quellenangabe
  • 9(2):105
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.3390/nu9020105 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331536/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Lychee seed is a traditional Chinese medicine and possesses many activities, including hypoglycemia, liver protection, antioxidation, antivirus, and antitumor. However, its effect on neuroprotection is still unclear. The present study investigated the effects of lychee seed saponins (LSS) on neuroprotection and associated mechanisms. We established a rat model of Alzheimer’s disease (AD) by injecting Aβ25–35 into the lateral ventricle of rats and evaluated the effect of LSS on spatial learning and memory ability via the Morris water maze. Neuronal apoptosis was analyzed by hematoxylin and eosin stain and terminal deoxynucleotidyl transferase (Tdt)-mediated dUTP nick-end labeling analysis, and mRNA expression of caspase-3 and protein expressions of Bax and Bcl-2 by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting, respectively. The results showed that LSS remarkably improved cognitive function and alleviated neuronal injury by inhibiting apoptosis in the hippocampus of AD rats. Furthermore, the mRNA expression of caspase-3 and the protein expression of Bax were downregulated, while the protein expression of Bcl-2 and the ratio of Bcl-2/Bax were increased by LSS. We demonstrate that LSS significantly improves cognitive function and prevent neuronal injury in the AD rats via regulation of the apoptosis pathway. Therefore, LSS may be developed as a nutritional supplement and sold as a drug for AD prevention and/or treatment.
1000 Sacherschließung
lokal cognitive function
lokal lychee seed saponins
lokal rat model of Alzheimer’s disease
lokal Alzheimer’s disease
lokal neuronal injury
lokal apoptosis
1000 Fachgruppe
  1. Medizin |
  2. Ernährungswissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/V2FuZywgWGl1bGluZw==|http://orcid.org/0000-0002-6136-7469|https://frl.publisso.de/adhoc/creator/WXUsIENob25nbGlu|https://frl.publisso.de/adhoc/creator/VGFuZywgWW9uZw==|https://frl.publisso.de/adhoc/creator/TGl1LCBKaWFu|https://frl.publisso.de/adhoc/creator/Q2hlbiwgSGFpeGlh|https://frl.publisso.de/adhoc/creator/SmluLCBCaW5namlu|https://frl.publisso.de/adhoc/creator/TWVpLCBRaWJpbmc=|https://frl.publisso.de/adhoc/creator/Q2FvLCBTaG91c29uZw==|https://frl.publisso.de/adhoc/creator/UWluLCBEYWxpYW4=
1000 Label
1000 Förderer
  1. Sichuan Province
  2. Educational Commission of Sichuan Province
  3. Southwest Medical University
1000 Fördernummer
  1. 2008SZ0050; LZ-LY-38
  2. 10ZA035
  3. 2010ZD-010
1000 Förderprogramm
  1. Science and Technology Planning
  2. -
  3. Key Development; Distinguished Professor Research Startup
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6412503.rdf
1000 Erstellt am 2019-02-01T12:27:37.747+0100
1000 Erstellt von 122
1000 beschreibt frl:6412503
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet 2020-01-30T19:35:47.682+0100
1000 Objekt bearb. Fri Feb 01 12:28:34 CET 2019
1000 Vgl. frl:6412503
1000 Oai Id
  1. oai:frl.publisso.de:frl:6412503 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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