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Overbeek-et-al_2018_Sex- and site-specific differences in colorectal cancer risk among people with type 2 diabetes.pdf 523,35KB
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1000 Titel
  • Sex- and site-specific differences in colorectal cancer risk among people with type 2 diabetes
1000 Autor/in
  1. Overbeek, Jetty A. |
  2. Kuiper, Josephina G. |
  3. van der Heijden, Amber A. W. A. |
  4. Labots, Mariette |
  5. Haug, Ulrike |
  6. Herings, Ron M. C. |
  7. Nijpels, Giel |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-11-12
1000 Erschienen in
1000 Quellenangabe
  • 34(2): 269-276
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1007/s00384-018-3191-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331739/ |
1000 Ergänzendes Material
  • https://link.springer.com/article/10.1007%2Fs00384-018-3191-7#SupplementaryMaterial |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • PURPOSE: The prevalence of colorectal cancer is higher among patients with type 2 diabetes mellitus (T2D) than among patients without diabetes. Furthermore, men are at higher risk for developing colorectal cancer than women in the general population and also subsite-specific risks differ per sex. The aim was to evaluate the impact of T2D on these associations. METHODS: A population-based matched cohort study was performed using data from the PHARMO Database Network. Patients with T2D were selected and matched (1:4) to diabetes free controls. Cox proportional hazards models were used to estimate hazard ratios (HRs) for CRC and its subsites. HRs were determined per sex and adjusted for age and socioeconomic status. The ratio of distal versus proximal colon cancer was calculated for people with T2D and controls per sex and stratified by age. RESULTS: Over 55,000 people with T2D were matched to > 215,000 diabetes free controls. Men and women with T2D were 1.3 times more likely to develop colorectal cancer compared to controls. Men with T2D were at higher risk to develop distal colon cancer (hazard ratio (95% confidence interval), 1.42 (1.08–1.88)), and women with T2D were at higher risk for developing proximal colon cancer (hazard ratio (95% confidence interval), 1.58 (1.13–2.19)). For rectal cancer, no statistically significant risk was observed for both men and women. CONCLUSIONS: Sex-specific screening strategies and prevention protocols should be considered for people with T2D. More tailored screening strategies may optimize the effectiveness of colorectal cancer screening in terms of reducing incidence and mortality.
1000 Sacherschließung
lokal Proximal colon cancer
lokal Distal colon cancer
lokal Type 2 diabetes
lokal Right-sided colon cancer
lokal Sidedness
lokal Left-sided colon cancer
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/T3ZlcmJlZWssIEpldHR5IEEu|https://frl.publisso.de/adhoc/creator/S3VpcGVyLCBKb3NlcGhpbmEgRy4=|https://frl.publisso.de/adhoc/creator/dmFuIGRlciBIZWlqZGVuLCBBbWJlciBBLiBXLiBBLg==|https://frl.publisso.de/adhoc/creator/TGFib3RzLCBNYXJpZXR0ZQ==|https://orcid.org/0000-0002-1886-2923|https://frl.publisso.de/adhoc/creator/SGVyaW5ncywgUm9uIE0uIEMu|https://frl.publisso.de/adhoc/creator/TmlqcGVscywgR2llbA==
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1000 Fördernummer
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1000 Dateien
  1. Sex- and site-specific differences in colorectal cancer risk among people with type 2 diabetes
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1000 @id frl:6413154.rdf
1000 Erstellt am 2019-03-01T11:59:31.932+0100
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1000 Zuletzt bearbeitet 2022-05-31T15:49:40.187+0200
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