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WeightNameValue
1000 Titel
  • The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels
1000 Autor/in
  1. Valkova, Christina |
  2. Liebmann, Lutz |
  3. Krämer, Andreas |
  4. Hübner, Christian A. |
  5. Kaether, Christoph |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-01-24
1000 Erschienen in
1000 Quellenangabe
  • 7:41248
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/srep41248 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28117367/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/srep41248#supplementary-information |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Rer1 is a sorting receptor in the early secretory pathway that controls the assembly and the cell surface transport of selected multimeric membrane protein complexes. Mice with a Purkinje cell (PC) specific deletion of Rer1 showed normal polarization and differentiation of PCs and normal development of the cerebellum. However, PC-specific loss of Rer1 led to age-dependent motor deficits in beam walk, ladder climbing and gait. Analysis of brain sections revealed a specific degeneration of PCs in the anterior cerebellar lobe in old animals. Electrophysiological recordings demonstrated severe deficits in spontaneous action potential generation. Measurements of resurgent currents indicated decreased surface densities of voltage-gated sodium channels (Nav), but not changes in individual channels. Analysis of mice with a whole brain Rer1-deletion demonstrated a strong down-regulation of Nav1.6 and 1.1 in the absence of Rer1, whereas protein levels of the related Cav2.1 and of Kv3.3 and 7.2 channels were not affected. The data suggest that Rer1 controls the assembly and transport of Nav1.1 and 1.6, the principal sodium channels responsible for recurrent firing, in PCs.
1000 Sacherschließung
lokal Cellular neuroscience
lokal Endoplasmic reticulum
1000 Fachgruppe
  1. Medizin |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/VmFsa292YSwgQ2hyaXN0aW5h|https://frl.publisso.de/adhoc/creator/TGllYm1hbm4sIEx1dHo=|https://orcid.org/0000-0002-3765-1574|https://frl.publisso.de/adhoc/creator/SMO8Ym5lciwgQ2hyaXN0aWFuIEEu|https://frl.publisso.de/adhoc/creator/S2FldGhlciwgQ2hyaXN0b3Bo
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft (DFG) |
1000 Fördernummer
  1. KA1751/2-2; HU 800/10-1
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer KA1751/2-2; HU 800/10-1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6413804.rdf
1000 Erstellt am 2019-04-04T14:38:59.239+0200
1000 Erstellt von 285
1000 beschreibt frl:6413804
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Jan 30 19:42:30 CET 2020
1000 Objekt bearb. Mon Apr 08 13:47:16 CEST 2019
1000 Vgl. frl:6413804
1000 Oai Id
  1. oai:frl.publisso.de:frl:6413804 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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