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WeightNameValue
1000 Titel
  • Global Hippocampal Volume Reductions and Local CA1 Shape Deformations in Amyotrophic Lateral Sclerosis
1000 Autor/in
  1. Machts, Judith |
  2. Vielhaber, Stefan |
  3. Kollewe, Katja |
  4. Petri, Susanne |
  5. Kaufmann, Joern |
  6. Schoenfeld, Mircea Ariel |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-07-20
1000 Erschienen in
1000 Quellenangabe
  • 9:565
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fneur.2018.00565 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062964/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • There is increasing evidence for hippocampal involvement in Amyotrophic Lateral Sclerosis (ALS). Recent neuroimaging studies have been focused on disease-related hippocampal volume alterations while changes in hippocampal shape have been investigated less frequently. Here, we aimed to characterize the patterns of hippocampal degeneration using both an automatic and manual volumetric and surface-based approach in a group of 31 patients with ALS and 29 healthy controls. Irrespective of the segmentation type, left, and right hippocampal volumes were significantly reduced in ALS compared to controls. Local shape alterations were identified in the hippocampal head region of patients with ALS that corresponds to the cornu ammonis field 1 (CA1), a region known to be involved in novelty detection, memory processing, and integration of hippocampal input and output information. The results suggest a global hippocampal volume loss in ALS that is complemented by local shape deformations in a highly interconnected region within the hippocampus.
1000 Sacherschließung
lokal CA1
lokal structural MRI
lokal hippocampus
lokal ALS
lokal shape analysis
1000 Fachgruppe
  1. Medizin |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/TWFjaHRzLCBKdWRpdGg=|https://frl.publisso.de/adhoc/creator/VmllbGhhYmVyLCBTdGVmYW4=|https://frl.publisso.de/adhoc/creator/S29sbGV3ZSwgS2F0amE=|https://frl.publisso.de/adhoc/creator/UGV0cmksIFN1c2FubmU=|https://frl.publisso.de/adhoc/creator/S2F1Zm1hbm4sIEpvZXJu|https://orcid.org/0000-0001-9003-4092
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1000 Erstellt am 2019-04-05T11:04:08.159+0200
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1000 Zuletzt bearbeitet Thu Jan 30 19:41:48 CET 2020
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1000 Oai Id
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