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1000 Titel
  • Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle
1000 Autor/in
  1. Ahrens, Hellen E. |
  2. Huettemeister, Judith |
  3. Schmidt, Manuel |
  4. Kaether, Christoph |
  5. von Maltzahn, Julia |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-07-04
1000 Erschienen in
1000 Quellenangabe
  • 8(1):20
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s13395-018-0166-x |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29973273/ |
1000 Ergänzendes Material
  • https://skeletalmusclejournal.biomedcentral.com/articles/10.1186/s13395-018-0166-x#Decs |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Klotho is a well-known anti-aging hormone, which serves as a suppressor of aging through a variety of mechanisms. Aging of skeletal muscle is concomitant with a decrease in muscle stem cell function resulting in impaired regeneration. METHODS: Here we investigate the functional role of the anti-aging hormone Klotho for muscle stem cell function after cardiotoxin-induced injury of skeletal muscle using a klotho hypomorphic mouse line, which is characterized by a premature aging phenotype. Furthermore, we perform floating single myofiber cultures with their adjacent muscle stem cells to investigate the interplay between canonical Wnt signaling and Klotho function. RESULTS: We demonstrate that muscle stem cell numbers are significantly decreased in klotho hypomorphic mice. Furthermore, we show that muscle stem cell function is also severely impaired upon loss of klotho expression, in culture and during regeneration in vivo. Moreover, we demonstrate that addition of recombinant Klotho protein inhibits aberrant excessive Wnt signaling in aged muscle stem cells thereby restoring their functionality. CONCLUSIONS: The anti-aging hormone Klotho counteracts aberrant canonical Wnt signaling in muscle stem cells and might be one of the naturally occurring inhibitors of canonical Wnt signaling in skeletal muscle.
1000 Sacherschließung
lokal Klotho
lokal Aging
lokal Canonical Wnt signaling, Wnt3a
lokal Myogenesis
lokal Regeneration
lokal Muscle stem cell
lokal Skeletal muscle
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/QWhyZW5zLCBIZWxsZW4gRS4=|https://frl.publisso.de/adhoc/creator/SHVldHRlbWVpc3RlciwgSnVkaXRo|https://frl.publisso.de/adhoc/creator/U2NobWlkdCwgTWFudWVs|https://frl.publisso.de/adhoc/creator/S2FldGhlciwgQ2hyaXN0b3Bo|https://orcid.org/0000-0001-7674-1487
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. Leibniz-Gemeinschaft |
1000 Fördernummer
  1. MA-3975/2-1
  2. SAW2015
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer MA-3975/2-1
  2. 1000 joinedFunding-child
    1000 Förderer Leibniz-Gemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer SAW2015
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6413926.rdf
1000 Erstellt am 2019-04-10T13:44:47.724+0200
1000 Erstellt von 285
1000 beschreibt frl:6413926
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Wed May 29 12:14:34 CEST 2019
1000 Objekt bearb. Wed May 29 12:14:22 CEST 2019
1000 Vgl. frl:6413926
1000 Oai Id
  1. oai:frl.publisso.de:frl:6413926 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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